The primary objective of this study is to assess how selective attention to different food characteristics (calories, taste intensity and pleasantness) affects brain responses during tasting. Secondary objectives are to assess (1) whether taste…
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Brief title
Condition
- Other condition
Synonym
Health condition
eetgedrag
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter/endpoint is brain activation during tasting.
Secondary outcome
The secondary parameter/endpoint is ad libitum food intake.
Background summary
How our brains respond to a mouthful of food depends on the attention we pay to
it*s different characteristics. In fMRI taste research, instructions
accompanying a taste are often very unspecific. This allows participants to
focus their attention on various aspects of the food which makes it difficult
to pinpoint very precisely what the associated brain activation reflects.
Study objective
The primary objective of this study is to assess how selective attention to
different food characteristics (calories, taste intensity and pleasantness)
affects brain responses during tasting.
Secondary objectives are to assess (1) whether taste activation during
selective attention to calories, taste intensity or pleasantness best predicts
food intake, (2) to assess whether taste activation during selective attention
is the same for different taste qualities and (3) to assess whether taste
activation during selective attention is modulated by personality
characteristics.
Study design
On the study day participants engage in a taste fMRI task in which they are
instructed to alternately pay attention to the calories (C), taste intensity
(T) and pleasantness (P) of a savory, a sweet and a neutral drink. At the end
of the session (outside the scanner) participants will be asked to consume as
much as they want from the sweet drink (ad libitum).
Intervention
Participants are instructed to pay attention to either the calories, taste
intensity or pleasantness of a sweet, a savory and a neutral stimulus and
accordingly taste these stimuli.
Study burden and risks
The study will consist of a screening session (approx. 60 min), a training
session (approx. 60 min) and a scan session (approx. 90 min). Participants will
visit the university once for the screening session. After this, participants
complete the training session in a dummy scanner (Restaurant of the Future,
Wageningen). For the fMRI scan session, participants will visit the MRI
facility in Hospital Gelderse Vallei (Ede). During the fMRI scan, subjects will
be exposed to visual cues/instructions and taste small amounts of the stimuli.
After that, they will consume a product ad libitum. In addition, participants
will complete several questionnaires and perform sensory ratings of the three
test stimuli. The study is non-therapeutic to the participants. The risk
associated with participation is negligible.
Bomenweg 2
Wageningen 6703 HD
NL
Bomenweg 2
Wageningen 6703 HD
NL
Listed location countries
Age
Inclusion criteria
-Gender: female
-Age: 18-35 year
-BMI: 18.5 - 25.0 kg/m2
-Healthy (as judged by the participant)
-Being right handed
Exclusion criteria
-Restraint eating (women: score > 2.80)
-Lack of appetite
-Having difficulties with tasting, smelling, swallowing or eating
-Usage of an energy restricted diet during the last two months (preceding the screening session)
-Weight loss or weight gain of 5 kg or more during two months (preceding the screening session)
-Stomach or bowel diseases
-Diabetes, thyroid disease, kidney disease and other chronical disorders
-Having epilepsy or other neurological disorders
-Having claustrophobia, schizophrenia or another mental illness
-Usage of daily medication other than oral contraceptives, paracetamol or H1-antihistaminergic drugs
-Pregnancy during the last 6 months, having the intention to become pregnant or lactating
-Smoking on average more than one cigarette/cigar a day
-Being allergic/intolerant for products under study
-Disliking the beverages under study
-Working or doing an internship/thesis at the Department of Human Nutrition (WUR)
-Current participation in other (medical) research (except the EetMeetWeet study)
-Having a history of or current alcohol consumption of on average more than 21 units per week
-Having a contra-indication to MRI scanning
-Having objections against being informed about incidental findings of pathology and against the general physician being informed about incidental findings of pathology
-Presence of non-removable piercings
-Presence of tattoos with iron pigments
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL52691.081.15 |