to investigate pathogenic mechanisms in synovial tissue driving inflammatory rheumatic diseases in relationship to phenotype, disease duration and stage and in relation to systemic immunity, to identify new diagnostic and therapeutic targets.
ID
Source
Brief title
Condition
- Autoimmune disorders
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
This concerns a transversal cohort investigation involving mechanistic,
exploratory and descriptive analyses. There is no primary study outcome.
Secondary outcome
This concerns a transversal cohort investigation involving mechanistic,
exploratory and descriptive analyses. There is no primary study outcome.
Background summary
Rheumatic inflammatory diseases are prevalent, invalidating conditions that
manifest in inflammation of joint capsules, muscles, connective tiisue and/or
tendons. Often other tissues and/or organs are involved such as airways and
secretory glands. The disease courses vary between individual, even between
those with a similar phenotype. The cause and mechanisms of inflammatory
rheumatic diseases and the differences there-in between individuals are largely
unknown.
Study objective
to investigate pathogenic mechanisms in synovial tissue driving inflammatory
rheumatic diseases in relationship to phenotype, disease duration and stage and
in relation to systemic immunity, to identify new diagnostic and therapeutic
targets.
Study design
Mechanistic and descriptive biologic analyses in a transversal patient cohort.
Study burden and risks
A proportion of patients suffers from a post-punctional hematoma after blood
withdrawal or synovial biopsy.
Geert Grooteplein-zuid 10
Nijmegen 6525GA
NL
Geert Grooteplein-zuid 10
Nijmegen 6525GA
NL
Listed location countries
Age
Inclusion criteria
patients with inflammatory rheumatic disease with active arthritis.
Older than 18 years of age.
Exclusion criteria
active inflammatory or infectious co-morbid disease.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54055.091.15 |