Primary Objective: To determine the effect of omega-3 PUFAs on exercise performance. Secondary Objective: To determine the effect of omega-3 polyunsaturated fatty acids supplementation on performance determining variables, such as VO2max, VO2 at the…
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Source
Brief title
Condition
- Other condition
Synonym
Health condition
Geen aandoeningen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are exercise performance (time trail) and the
underlying performance-determining variables (VO2max, VO2 at the ventilatory
threshold, anaerobic capacity, and gross efficiency) which are determined pre
and post intervention.
Secondary outcome
In addition to the exercise tests, blood samples and ultrasound measurements
will be taken pre- and post-intervention.
Background summary
In sports in which both a high peak power and a high maximal sustainable power
is required, like in speed skating and rowing, oxygen supply is limiting
concurrent improvement of both traits. Hypoxia during strenuous exercise is
associated with oxidative stress and muscle damage which causes muscle protein
degradation rather than hypertrophy. We hypothesize that for athletes to
improve their peak power and endurance capacity myoglobin (Mb) concentration in
their muscle cells needs to be increased. Recent evidence suggests that
supplementation of omega-3 polyunsaturated fatty acids (PUFAs) stimulates
expression of myoglobin particularly in hypoxic conditions. We hypothesize that
in rowers and speed skaters supplementation of omega-3 PUFAs will concurrently
improve the maximal anaerobic and aerobic performances. In speed skaters the
effect will be larger than in rowers.
Study objective
Primary Objective: To determine the effect of omega-3 PUFAs on exercise
performance. Secondary Objective: To determine the effect of omega-3
polyunsaturated fatty acids supplementation on performance determining
variables, such as VO2max, VO2 at the ventilatory threshold, anaerobic
capacity, and gross-efficiency (GE).
Study design
A double-blind randomized placebo-controlled parallel group (rowers and speed
skaters) design will be used to study the effect of omega-3 polyunsaturated
fatty acids on exercise performance.
Intervention
One group receives twice daily 2 capsules with an omega-3 supplement (Trimare
fish oil, 1000 mg per capsule containing 600 mg omega-3) for six weeks. The
placebo group will receive twice daily 2 capsules corn oil supplement (1000 mg
per capsule) for six weeks as well.
Study burden and risks
Subjects will come to the lab for testing eight times: two times for blood
sampling and completing questionnaires, and 6 times for the exercise tests
which will take 30 minutes to 2 hours. The expected risk of emergencies is
extremely low. Some side effects may occur and give some discomfort but these
are deemed minor given de dose of supplements. If the results show that omega-3
supplementation improves muscle function this may have a major impact on the
success of the athletes* performances in competitions such as the Olympic
games.
Van der Boechorststraat 9
Amsterdam 1081 BT
NL
Van der Boechorststraat 9
Amsterdam 1081 BT
NL
Listed location countries
Age
Inclusion criteria
Rowers
- Male or female
- Member of the Dutch National Rowing Team or the talent team of the Dutch Rowing Team.
- Aged 18-45.
- Rated as low risk participant, based on the anamnesis form (see protocol; chapter 14.1).;Speed skaters
- Male or female
- Speed skater of the track selection Haarlem, regional talent centre Haarlem, marathon speed skating team Haven Amsterdam/SKITS or being an elite international speed skater.
- Aged 18-45 year.
- Rated as low risk participant, based on the anamnesis form (see protocol; chapter 14.1).
Exclusion criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Use of omega-3 PUFA supplements in the month prior to the start of the study
- No low risk classification based on the anamnesis form (appendix 1; chapter 14.1).
- Use of blood thinners.
- Low blood pressure (diastolic < 60 and/or systolic < 90 mmHg) combined with regular dizziness in rest or during daily activities.
- Pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
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In other registers
| Register | ID |
|---|---|
| CCMO | NL54282.029.15 |