This study attempts to explore the relation between the functioning of the schema-related mPFC, REM sleep and affective memory bias, by simulating a depressive-like state in healthy subjects through negative mood induction and applying rTMS to…
ID
Source
Brief title
Condition
- Other condition
- Mood disorders and disturbances NEC
Synonym
Health condition
neurowetenschappelijk onderzoek
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are the amount of items remembered (hits), amount of
critical lures remembered (FA) in all groups and subjective measures (e.g. mood
induction check).
Secondary outcome
The secondary study parameters are the measured sleep parameters e.g. amount of
REM sleep and amount of frontal theta and gamma power.
Background summary
Medial prefrontal cortex (mPFC) related schema processing appears readily as a
candidate mechanism accounting for memory bias in depressed patients.
Furthermore, REM sleep has been suggested as pivotal for the processing of
affective memories and as an alternative pathway of consolidation for
schema-conformant memories. The intimate interactions between schema memory,
memory bias in depression and sleep have however not been systematically
investigated yet. This study could provide us with a deeper understanding of
mechanisms underlying memory biases in depression and lead to possible
therapeutic advances.
Study objective
This study attempts to explore the relation between the functioning of the
schema-related mPFC, REM sleep and affective memory bias, by simulating a
depressive-like state in healthy subjects through negative mood induction and
applying rTMS to inhibit mPFC processing before the encoding of a
schema-related false memory task, followed by full-night sleep recordings.
Study design
A between-subject design will be employed with four groups of healthy adult
volunteers, balanced between mood induction (neutral or negative) and TMS
stimulation (on the mPFC or primary somatosensory cortex control region). The
study will include one initial intake session and two experimental sessions and
two nights of sleep recording at home. On the first experimental session, after
mood induction (neu/neg) and cTBS rTMS (mPFC/leg representational area of the
primary motor cortex), the encoding session of an adapted DRM (false memory)
paradigm will probe mood-related schema memory. On the second experimental
session, participants will be tested on their memory in a recall/recognition
task. Two nights of sleep will be recorded at home with an ambulant sleep
recording device, one after intake and one between the two experimental
sessions
Intervention
The intervention includes a previously established off-line rTMS-protocol with
the intention to produce short-term inhibitory effects on the functioning of
the target region (mPFC). The intervention will consist of a standard
continuous theta-stimulation (cTBS) procedure, consisting of a total of 600
pulses across 40 sec at 80% of the measured aMT of the tibialis anterior and
120% of the first dorsal interosseous. The stimulation protocol is patterned,
and consists of bursts of 3 pulses at 50 Hz, and each burst is repeated at 5Hz.
Study burden and risks
All measurements will be administered during three visits at the institute and
during two nights of sleep. For the assessment of risks and burden associated
with transcranial brain stimulation in this study please refer section 10.2, as
well as paragraph 5.2 of the approved Standard Operating Procedure for
Non-Invasive Brain Stimulation (v. 2.1., CMO No. 2013/245) at the Donders
Institute for Brain, Cognition and Behaviour. This study will be conducted in
accordance with the guidelines implemented within the SOP NIBS. All
participants are screened for their relevant medical history and other TMS
safety aspects. There are no risk factors related neither to the false memory
task nor to the sleep recording. Subjects are asked to sleep with an ambulant
sleep recording device on two consecutive nights during the study. A small
amount of electrodes are attached to the scalp and a band will be placed across
the chest, which may be experienced as a small burden during sleep initiation.
The study will broaden our understanding of the involvement of mPFC related
schema memories and the effect rTMS effect on mood congruent memories, which
may have clinical implications.
Kapittelweg 29
Nijmegen 6525 EN
NL
Kapittelweg 29
Nijmegen 6525 EN
NL
Listed location countries
Age
Inclusion criteria
Only healthy, competent participants, 18*45 years old, with normal vision or corrected to
normal vision by means of contact lenses.
Exclusion criteria
Skin diseases at intended electrode sites (EMG, EEG, tCS)
(History of) psychiatric disorder/ treatment
(History of) neurological disorder/ treatment
Disorders of vision (i.e., deviation from *normal or corrected-to-normal vision*)
Any prescribed medication that can alter cortical excitability (e.g. antiepileptics, tricyclicanti-depressives or benzodiazepines) or can have an influence on the participant*s vigilance or cognitive performance within two weeks prior to participation
Having minimal sleep, or excess consumption of alcohol/recreational drugs/caffeine in the 24 hours prior to the experimental TMS session.
(History of) sleep disorder
Shift work for the past 3 months
Transmedial flights for the past month
Extreme chronotype
Regular nappers
Extreme caffeine consumers
Heavy smokers
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL57736.091.16 |
| OMON | NL-OMON27450 |