The primary objectives are to study how exercise (i.e. actively performing exercise) affects frontal cortical activation (neurovascular coupling) and the effects on immediate cognitive performance of short periods of reduced and enhanced cerebral…
ID
Source
Brief title
Condition
- Dementia and amnestic conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in functional prefrontal activation as determined by oxygenated
hemoglobin changes (µmol/L) induced by cerebral blood flow perturbations.
Secondary outcome
-
Background summary
Human and animal studies show the positive effects of regular physical exercise
on cognitive functioning. Epidemiological studies have shown that leisure-time
physical activity at midlife is associated with a decreased risk of Alzheimer
disease (AD) later in life. The underlying mechanisms by which exercise could
modify cognitive performance in humans remains largely unclear. This project
aims to unravel the potential role of cerebral blood flow regulation as a key
factor, or mediator, for the beneficial effects of exercise on brain function.
Study objective
The primary objectives are to study how exercise (i.e. actively performing
exercise) affects frontal cortical activation (neurovascular coupling) and the
effects on immediate cognitive performance of short periods of reduced and
enhanced cerebral blood flow in healthy elderly participants.
Study design
This is an intervention study with a cross-over design.
Intervention
Healthy older adults will visit the hemodynamics laboratory three times. During
one visit participants will have to perform sit-to-stand alternations for four
times five minutes in total, with intervals of one minute. During another visit
participants will exercise on a pedal exercise at 65% of their theoretical
maximum heart rate for approximately 40 minutes. To minimize effects of
fatigue, participants will be able to rest 10 minutes halfway the task.
Study burden and risks
Given the established safety of the noninvasive techniques there are no
foreseeable risks associated with participation in this study. A considerable
burden will be placed on the participating healthy elderly because the three
lab visits are time-consuming.
Reinier Postlaan 4
Nijmegen 6500HB
NL
Reinier Postlaan 4
Nijmegen 6500HB
NL
Listed location countries
Age
Inclusion criteria
Males and females aged >=60
Living independently at home
Physical ability sufficient to allow performance of exercise
Normal or corrected-to-normal vision
Stable medical condition for more than 6 months
Stable medications for more than 2 months
Exclusion criteria
Experience of subjective memory problems
History of serious neurological disorder
History of any major psychiatric disorder
Significant history of alcoholism or drug abuse within the last 10 years
History of myocardial infarction within previous year
Unstable cardiac, renal, lung, liver, or other chronic disease
Uncontrolled hypertension or hypotension
Congestive heart failure (NYHA class II, III or IV)
Diabetes
Use of psychopharmacological drugs
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL56843.091.16 |