The objective is to investigate the correlation between bacterial/viral gut infections and acute appendicitis in children.
ID
Source
Brief title
Condition
- Gastrointestinal inflammatory conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are the bacteria and viruses present, and their
mutual frequence ratio, in the wall of the resected inflamed appendix together
with the presence of these bacteria and gastrointestinal viruses in feces and
the viruses in the blood samples.
Secondary outcome
Other parameters that will be analyzed are patient factors like diagnosis
(perforated or non-perforated appendicitis), age and gender. Furthermore,
information on possible confounding factors, such as use of antibiotics or
other medicine, use of probiotics, and diet, will be collected.
Background summary
Appendicitis is the most common reason for abdominal surgery in children.
Appendicitis and surgery performed on acute appendicitis still causes morbidity
and complications. The first step in prevention would therefore be to know
more about the pathogenesis of appendicitis.
Appendicitis is caused by obstruction of the lumen; this may be due to a
feacolith or enlarged peri- appendiceal lymph nodes. It has been hypothesized
that specific viral or bacterial infections causes enlargement of these lymph
nodes and may therefore play a role in the pathogenesis of acute appendicitis
in children.
Study objective
The objective is to investigate the correlation between bacterial/viral gut
infections and acute appendicitis in children.
Study design
Prospective observational multicenter study
Study burden and risks
There is no direct benefit for the patients who are participating in this
study. But the burden for the patients is also minimal. The extra blood sample
of 6 ml will be collected simultaneously with the routine blood sampling.
Therefore, no extra venapuncture is necessary. The biopsy from the base of the
appendix will be taken after excision and therefore gives no additional risk.
Furthermore, the collection of a fecal sample is not invasive and can be send
to the UMCG, so it does not extent the time at the emergency department.
Finally, filling in the questionnaire is not a burden for the health of the
children.
This research may be in the future an important contribution to diagnose
children with suspected appendicitis faster, and contributes to possible new
treatment methods for appendicitis.
Hanzeplein 1
Groningen 9700RB
NL
Hanzeplein 1
Groningen 9700RB
NL
Listed location countries
Age
Inclusion criteria
Children between 5 and 18 years old, who are referred by first line health care with the suspicion of acute appendicitis.
Healthy children between 5 and 18 years old
Exclusion criteria
Severe co-morbidity like malignancy, resent abdominal surgery and known inflammatory bowl disease.
Pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL57448.042.16 |