To investigate contributions of the angular gyrus in recollection processes.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
fundamenteel onderzoek bij gezonde vrijwilligers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main objective of this study is to investigate whether activity in the
angular gyrus is necessary for recollection processes in recognition memory.
Secondary outcome
Not applicable
Background summary
It has been proposed by dual-process theories that recognition memory consists
of familiarity and recollection processes (Jacoby & Dallas, 1981; Mandler,
1980). Familiarity memory processes are responsible for recognition without
context, while recollection memory processes are responsible for recognition
with context (Yonelinas, 2002).
A review focusing solely on the parietal cortex, indicated that
recollection-related activation is localized in the angular gyrus (AG; BA 39;
Vilberg & Rugg, 2008). However, disentangling the role of brain activation can
be challenging in fMRI research. Brain activation in a brain region while
performing a memory task, is indicative of that brain region playing a role in
the execution of the task. However, it does not indicate that that brain region
is necessary to perform the memory task. Only when disrupting or enhancing the
function of a brain region influences the performance on the task, there is an
indication for a critical role of that brain region.
Up until now, little research has been done looking at the involvement of the
left angular gyrus in familiarity and recollection.
Study objective
To investigate contributions of the angular gyrus in recollection processes.
Study design
A randomized controlled within-subject design. The experiment consists of three
sessions, one intake session and two test sessions on three separate days. In
the test sessions, participants will perform a recognition memory task. In one
of the two test sessions, participants will receive a 20 minutes 1 Hz train of
inhibitory rTMS targeting the left angular gyrus. RTMS to the vertex will serve
as the active control condition as this region is not directly implicated in
memory processes. The location of stimulation will be determined by
neuronavigation using predetermined coordinates from literature (Vilberg &
Rugg, 2008). Test sessions will be randomized and counterbalanced across
participants.
Intervention
1 Hz sub threshold repetitive transcranial magnetic stimulation (1200 pulses).
Study burden and risks
The currently proposed TMS paradigm does not carry any significant risks.
Safety guidelines as acknowledged by the International Federation of Clinical
Neurophysiology will be followed strictly. Potential side-effects are muscle
tension and headache. These are generally mild discomforts that respond
promptly to common analgesics. Volunteers can withdraw from the study at any
given time and there are no direct benefits for the participants.
Montessorilaan 3
Nijmegen 6525 HR
NL
Montessorilaan 3
Nijmegen 6525 HR
NL
Listed location countries
Age
Inclusion criteria
Between 18-35 years of age years, right-handed, non-smoking, normal or corrected-to-normal vision, Dutch as a native language
Exclusion criteria
Skin disease, metal in cranium, use of psychotropic drugs, including cannabis, XTC, amphetamines and cocaine, epilepsy or family history of epilepsy, history of closed-head injury, history of neurological or psychiatric disorders, medication use (i.e., benzodiazepines, antidepressants and neuroleptica), cardiac pacemaker, electronic hearing devices, pregnancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL56819.091.16 |