The aim of this study is to investigate the presence of the stripped occipital cortex in patients with the sporadic form of CAA.
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main parameter is the presence of the striped occipital cortex on 7T MRI.
Secondary outcome
Secondary parameters are other iron biomarkers such as microbleeds,
superficial siderosis, cortical subarachnoid haemorrhage and hypointensity of
the basal ganglia.
Background summary
One frequent cause of lobar (cortical) intracerebral hemorrhage (ICH) in the
elderly is sporadic cerebral amyloid angiopathy (sCAA). sCAA is characterized
by the deposition of amyloid-β peptide and degenerative changes in the
capillaries, arterioles, and small and medium sized arteries of the cerebral
cortex, leptomeninges, and cerebellum. Hereditary cerebral hemorrhage with
amyloidosis-Dutch type (HCHWA-D) is an autosomal dominant form of CAA, in which
the amyloid angiopathy is pathologically and biochemically similar to sCAA. The
disease is characterized by (repeated) intracerebral hemorrhage and cognitive
decline. Since in patients with HCHWA-D the genetic background is known it
offers a unique opportunity to investigate in vivo the role of these vascular
amyloid depositions on ICH progression, recurrence rate and outcome.
In the EDAN study (P11.094) we found a new MRI marker in patients with HCHWA-D
(figure 1). This so called *stripped cortex sign* is present on 7T MRI in
almost half of the HCHWA-D patients. The underlying pathophysiology of the
stripped cortex is unknown. Probably it reflects amyloid associated iron
depositions in the occipital region of the brain. It is unknown if the stripped
occipital cortex is also present in the sporadic form of CAA. Because the
diagnosis of sporadic CAA is difficult during life, a new biomarker could
improve future diagnostic abilities for CAA.
Study objective
The aim of this study is to investigate the presence of the stripped occipital
cortex in patients with the sporadic form of CAA.
Study design
Our study design is cross-sectional.
Study burden and risks
The potential risks are limited. The risks of 7T MRI are minimal (risk of every
day life), because there are no consequences to the health of the participant.
There is no benefit for the patients except for more insight into the
underlying pathophysiology of the hemorrhages related to their disease. This
study could eventually lead to a new biomarker for sCAA and improve the
possibility of diagnosing sCAA during life.
Albinusdreef 2 2
Leiden 2300 RC
NL
Albinusdreef 2 2
Leiden 2300 RC
NL
Listed location countries
Age
Inclusion criteria
Probable cerebral amyloid angiopathy according to the Boston criteria
Exclusion criteria
<18 jaar
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL57720.058.16 |