The objective of the study is to determine the prevalence of antibiotic resistant E. coli, S. aureus and K. pneumoniae strains in residents of Rotterdam visiting general practitioners in neighborhoods with low socioeconomic status (…
ID
Source
Brief title
Condition
- Ancillary infectious topics
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Prevalence (%) of antibiotic resistant E. coli, S. aureus and K. pneumoniae
strains in a population sample of residents of Rotterdam.
Secondary outcome
Associations between the presence of antibiotic resistance and riskfactors such
as age, sex, travel history, antibiotic use, hospital admissions and workplace.
Background summary
Although the Netherlands is still considered a country with a low prevalence of
multidrug-resistant bacteria, the risk of carbapenemase-producing
Enterobacteriaceae and other resistant bacteria have already been reported .
International travel and visiting international hospitals have been suggested
as important risk factors for the spread of antibiotic resistant bacteria
worldwide. Currently, there are no data on the prevalence of carriage of
antibiotic resistant strains in population of Rotterdam.
Study objective
The objective of the study is to determine the prevalence of antibiotic
resistant E. coli, S. aureus and K. pneumoniae strains in residents of
Rotterdam visiting general practitioners in neighborhoods with low
socioeconomic status (achterstandswijken).
Our secondary objectives are:
1. To examine potential associations between the presence of antibiotic
resistance and risk factors such as antibiotic use, travel history, hospital
admissions and workplace.
2. To assess the feasibility of the study design in this particular setting of
Rotterdam in anticipation of a larger population-wide prevalence study in
Rotterdam.
Study design
Cross-sectional prevalence study.
This is a pilot study, which next to assessing the primary and secondary
outcomes of the study, also determines feasibility in order to develop a more
comprehensive surveillance system in the neighborhoods of Rotterdam and develop
preventive interventions.
Study burden and risks
After informed consent, nasal and perianal swabs will be collected from the
participants along with a short questionnaire. This represents a very mild
burden for the participant, but does not produce any benefit because the study
is anonymous. However, there is a large potential public health benefit for the
community.
Schiedamsedijk 95
Rotterdam 3011 EN
NL
Schiedamsedijk 95
Rotterdam 3011 EN
NL
Listed location countries
Age
Inclusion criteria
1. Adult (18 years and older)
2. Physically and mentally able to consent and participate (capacitated)
3. Resident of Rotterdam
4. Officially enrolled in the GP practice where enrollment takes place
5. Provides informed consent
Exclusion criteria
All those not eligible according to the inclusion criteria. Additionally, a potential subject who shows inability to communicate with the research team in Dutch or otherwise, will also be excluded from the participation in the study.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL56740.078.16 |