The aim of the project is to study the effect of GRT on the synthesis and cytokine release in psoriasis lesions. This information can establish the right formulation and dose of GRT for further research.
ID
Source
Brief title
Condition
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cytokine synthesis and release after treatment with GRT.
Secondary outcome
Not applicable.
Background summary
Psoriasis is an auto-immune disease in which pro-inflammatory protein
mediators, released by skin cells and infiltrating cells, cause an abnormal
cell division and differentiation. It may be possible to treat psoriasis using
drugs aimed at preventing the synthesis of such mediators.
Study objective
The aim of the project is to study the effect of GRT on the synthesis and
cytokine release in psoriasis lesions. This information can establish the right
formulation and dose of GRT for further research.
Study design
Lesional skin biopsies of 3 mm in diameter will be treated with GRT in vitro.
By measuring the effect of the cytokine synthesis and release, it is possible
to establish the right formulation and dose of GRT for further research.
Study burden and risks
The health risks associated with taking skin biopsies are small. It is possible
to obtain a slight scar formation and/or discolouration at the site of the
biopsy punch.
Zieglerstraße 6
Aachen 52099
DE
Zieglerstraße 6
Aachen 52099
DE
Listed location countries
Age
Inclusion criteria
Patients with moderate to severe psoriasis
Exclusion criteria
Volunteers undergoing UV/light therapy or taking systemic drugs such as cyclosporin A or methotrexate
Volunteers using local topical corticosteroids
Volunteers developing psoriasis at wound sites (Köbner phenomenon)
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL56196.098.15 |