The main objective of this research is to find out if the blood flow velocity in the MCA changes after exercise for 1,5 hours and if this can be attributed to the loss of water.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
geen aandoening
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are the change in blood flow velocity in the MCA
measured by TCD and the change in weight after 1,5 hours of exercise. The study
is finished when 20 participants, in whom written consent has been obtained,
have successfully completed the entire study.
Secondary outcome
Not applicable
Background summary
During exercise temperature rises and the body has to cool itself. This is done
by sweating. Continuous exercising causes a considerable loss of water. This
will usually be compensated by drinking water. If water will not be drunk, then
the vascular system has less volume. This can also affect the blood flow
towards the brain.
Normally the cerebral autoregulation keeps the blood flow towards the brain
constant, within certain ranges. We hypothesize that after endurance exercising
the loss of water causes the MCA blood flow velocity to become more sys1
dominant and that the mean MCA blood flow velocity decreases.
Study objective
The main objective of this research is to find out if the blood flow velocity
in the MCA changes after exercise for 1,5 hours and if this can be attributed
to the loss of water.
Study design
A prospective intervention study. Participants will visit three times. The
VO2max will be calculated during the first visit. During the second and third
visit the participant has to cycle for 1,5 hours without water and with water,
respectively. Measurements will be done before and after the 1,5 hours of
exercise. Measurements include TCD, CO2, blood pressure and heart rate.
Intervention
Every participant has to cycle for 1,5 hours on 70% of their VO2max twice.
The first time they are not allowed to drink water and the second time they
will be given water at 45 minutes from the start. The amount of water is 70% of
the water lost during the first session.
Study burden and risks
The participant will be asked to visit three times. In total this will take
around 5 hours. There will be incentives for those that participate. The risks
associated with this study are negligible. 70% VO2max is sub-maximal and is
not considered to be discomforting to participants. All the measurements done
are non-invasive and safe.
Van Swietenplein 1
Groningen 9728 NT
NL
Van Swietenplein 1
Groningen 9728 NT
NL
Listed location countries
Age
Inclusion criteria
Exercises at least 2 times per week 1 hour endurance exercise
Exclusion criteria
Younger than 18 years old
Older than 35 years old
Answered yes 1 time or more on the PAR-Q form
Sweat disturbances
Insufficient temporal window for TCD investigation
Existing brain injury
Smoking
Diabetes
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL56381.099.16 |