The primary objective of this study is to get insight into the course of personality disorders in order to be better able to inform patients about their prognosis. We aim to identify factors associated with lower QoL and higher societal and medical…
ID
Source
Brief title
Condition
- Psychiatric disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Quality of life by means of the World Health Organization Quality of Life
Assessment BREF
Secondary outcome
Total costs of mental health
The Trimbos and Institute for Medical Technology Assessment Questionnaire on
Costs Associated with Psychiatric Illness and reference list for guidelines for
healthcare costs are used to assess direct and indirect costs. Quality-Adjusted
Life Year (QALY) is used as measure for life expectancy in number of years
corrected by quality of life (Short Form 12). One Qualy means one year in good
health. To conduct a costeffectiveness analysis the total extra costs before
onset of treatment are divided by the number of extra QALY*s in comparance to
the situation before treatment.
Structured Clinical Interview for DSM-IV axis II personality disorders
Mini International Neuropsychiatric Interview Plus
Costs Associated with Psychiatric Illness (TiC-P verkorte versie)
Questionnaire for Psychotic Experiences (QPE)
Korte Klachten Lijst / OQ45
Severity Indices of Personality Problems
Dissociative Experiences Scale
Jeugd Trauma Vragenlijst
Deel 3 Posttraumatic Diagnostic Scale
Hinting Task paradigm
Amsterdam Neuropsychological Tasks (ANT) - Identifying facial emotions subtest
WAIS III - Picture arrangement subtest
Davos Assessment of Cognitive Biases Scale (DACOBS)
Continuous Performance Test
Brief Cognitive Assessment Tool for Schizophrenia (including trail making test
B, digit symbol and verbal fluency test)
Background summary
Patients with personality disorders experience a variety of problems concerning
self esteem, temperament and social relations. Consequently, quality of life
(QoL) of these patients is low and societal costs are high. Depression, anxiety
and substance abuse often co-occur, as do psychotic symptoms which are usually
associated with multiple diagnoses and more severe childhood trauma. However,
patients with psychotic features and substance abuse were generally excluded
from studies, and (social) cognitive disturbances that are expected to co-occur
with psychotic features, have not been explored as a predictive factor so far.
It was commonly assumed that diagnoses of personality disorders are lifetime,
however, these diagnoses are not static. Symptoms fade, increase or transcend
into different psychiatric disorders, such as bipolar disorder or
schizophrenia. The literature does not provide sufficient information to be
able to predict who will have a bad prognosis.
Therefore, patients cannot be properly informed about their prognosis and it is
difficult to compose the appropriate patient based treatment.
Study objective
The primary objective of this study is to get insight into the course of
personality disorders in order to be better able to inform patients about their
prognosis. We aim to identify factors associated with lower QoL and higher
societal and medical costs in order to identify patients with these prognostic
features in an early stage. and may become a focus of treatment for patients
with severe personality disorders?
Study design
In this observational longitudinal study, data will be gathered at three points
in time, namely at baseline, 1 and 2 years thereafter, in order to monitor the
course of symptoms during the first 2 years after admission. At every time
point, all participants will be subjected to structured and semi-structured
standardized questionnaires and self-report questionnaires. Data regarding
cognitive functioning will be collected at baseline and two years after
admission.
Location
The study will be performed at the department of Personality Disorders, PsyQ,
The Hague, the Netherlands.
Statistical methods
With the aims of Statistical Package for the Social Sciences, version 20.0,
data will be analysed. Quality of life and total costs of healthcare are the
dependent valuables; possible predictive valuables will be used as covariates.
As these valuables can vary with change of time, multilevel-analysis will be
used as statistical method for continuous valuables of quality of life and
health care costs.
Study burden and risks
The collection of the data with questionnaires and cognitive tasks cost time.
For some patients questions regarding childhood trauma might be a burden.
During and at the end of the visits the investigator will inquire if the
patient has questions or increase of symptoms. If necessary an extra
appointment will be offered, or a caregiver will be consulted.
Lijnbaan 4
Den Haag 2512 VA
NL
Lijnbaan 4
Den Haag 2512 VA
NL
Listed location countries
Age
Inclusion criteria
-A personality disorder diagnosed with the Structured Clinical Interview for DSM-IV axis 2 personality disorders
-Age 18 years or older
-Written informed consent of the patient
Exclusion criteria
-Participants that cannot read, speak or understand Dutch
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL56118.058.16 |