Primary objective of this study is to assess changes in brain connectivity and activity in the Default Mode and Salience Network (hypothalamus, prefrontal cortex, nucleus accumbens, Ventral Tegmental Area) after different sugars and sweeteners.
ID
Source
Brief title
Condition
- Appetite and general nutritional disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in brain connectivity and activity, as measured by rsfMRI.
Secondary outcome
Psychophysical ratings of hunger, taste and sweetness
Background summary
The central role of the brain in regulating food intake and steering feeding
behaviour is increasingly recognized. It is currently well accepted that the
brain is the target organ to measure the effects of pleasantness, reward and
energy homeostasis in order to change feeding behaviour to reduce the rising
prevalence of obesity. The effects of food on the brain are multiple and
complex. In addition to primary aspects of food such as taste, texture, looks
and smell, secondary aspects such as energy regulation are as much important in
the entire *eating experience*. Using functional magnetic resonance imaging
(fMRI) we have previously measured the hypothalamic function during nutrient
ingestion.
In the present study we use resting state fMRI (rsfMRI) to detect changes in
connectivity in the default mode and salience network after consumption of four
different *milkshakes* with added sugars and sweeteners. Our overall hypothesis
is that sugar ingestion demonstrates the most extensive changes in rsFMRI since
both taste and energy homeostasis are being activated. Whereas sweeteners are
only expected to trigger the taste system. Secondary points of interest are the
(subtle) differences between the different sugars and sweeteners.
Study objective
Primary objective of this study is to assess changes in brain connectivity and
activity in the Default Mode and Salience Network (hypothalamus, prefrontal
cortex, nucleus accumbens, Ventral Tegmental Area) after different sugars and
sweeteners.
Study design
The study design is a randomized crossover observational study in healthy male
volunteers.
Intervention
Four different *milkshakes* of 165ml with added sugars and sweeteners.
Study burden and risks
The study will consist of four occasions. There will be an interval of at least
one week between the occasions. On all occasions, the subject will be admitted
to the Clinical Research Unit of the LUMC. After anthropometric measurements
(weight), rsFMRI will be performed after an ingestion of 165ml of a *milkshake*
with added sugars or sweeteners. Before and after the MRI the participants will
indicate their feelings of hunger and flavour and sweetness of the test product
on a VAS scale.
Olivier van Noortlaan 120
Vlaardingen 3133AT
NL
Olivier van Noortlaan 120
Vlaardingen 3133AT
NL
Listed location countries
Age
Inclusion criteria
Signed informed constent
Age between 18 and 25 years
Bodyweight of at least 70 kg
BMI between 20 and 23 kg/m2
Exclusion criteria
-Diabetes or history of other disturbances of glucose metabolism (eg impaired glucose tolerance, hypoglycemia).
-Any genetic or psychiatric disease (e.g. fragile X syndrome, major depression) affecting brain
-Any significant chronic disease
-Any known food allergies or intolerances
-Renal or hepatic disease
-Recent weight changes or attempts to lose weight (> 3 kg weight gain or loss, within the last 3 months)
-Smoking (current or last 6 months)
-Alcohol consumption of more than 21 units per week or use of recreational drugs at present or in the last year
-Recent participation in other biomedical research projects (within the last 3 months), participation in 3 or more biomedical research projects in one year
-Contra-indication to MRI scanning
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL55440.058.15 |