to determine the percentage of patients with CKD, without a history of gout or attacks of arthritis, that have tophi measured by US,DECT and clinical examination. to determine the percentage of patients with CKD, that have tophi measured by US, and…
ID
Source
Brief title
Condition
- Joint disorders
- Nephropathies
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The percentage of patients with MSU deposits on
- Dual Energy CT-scan
- Ultrasound
- Physical examination
The percentage of patients with erosions on
- conventional x-ray
Secondary outcome
Difference between patient with MSU deposits on examination in:
- Quality of life measured by the HAQ and SF-36
- Uric acid levels in serum
Background summary
Gout is a metabolic disorder of purine metabolism with primary manifestations
of acute and chronic arthritis , tophus formation and bone destruction. Gout is
more common in patients with chronic kidney disease (CKD). Tophi and gout
flares are associated with a lower quality of life and tophi can cause bone
erosions and joint destruction. Tophi and subsequent bone erosions can occur
without spells of arthritis (= asymptomatic gout). However data on the presence
of tophi and erosion in asymptomatic patients with renal failure is lacking.
Our hypothesis is that these can be detect in these patients with the use of
novel imaging techniques; dual energy computed tomography (DECT) and/or
ultrasound (US). In the future patients can be treated before they have
symptomatic gout and prevent the bone destruction by tophi leading to a
decrease in quality of life. In addition we will investigate the presence of
erosions and tophi in all patients with CKD.
Study objective
to determine the percentage of patients with CKD, without a history of gout or
attacks of arthritis, that have tophi measured by US,DECT and clinical
examination.
to determine the percentage of patients with CKD, that have tophi measured by
US, and clinical examination and or erosions measured by conventional x-ray.
Study design
Cross sectional cohort study
Study burden and risks
The burden consists of one extra 1,5 hour visit to the hospital in which 2
invasive investigations (Ultrasound and DECT scan/ x-ray) are performed. the
risk associated with these investigations is neglectable.
Benefit is that the patients are thoroughly screened for a treatable
comorbidity of renal failure.
's Gravendijkwal 230
Rotterdam 3015 CE
NL
's Gravendijkwal 230
Rotterdam 3015 CE
NL
Listed location countries
Age
Inclusion criteria
- eGFR <30 ml/min/1,73m2
- Chronic kidney disease (> 6months)
- 18 years or older
Exclusion criteria
- Poor knowledge of the Dutch language
- No written informed consent
- Pregnancy;
- Dialysis-dependency
Only for a selection of the patients:
- history of gout or history or attacks of arthritis
- Use of urate lowering drugs (iallopurinol, desuric and adenuric)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL53350.078.15 |