The main goal of the current project is to study whether a mindset of perceived control / loss of control over intake affects hormone release, brain reward processing, desire to eat and actual consumption.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
eetgedrag
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Food intake --> amount of chocolate intake in grams with bogus taste test
- Feelings of control --> questionnaires on feeling of craving and control
- Desire to eat --> questionnaires on desire to eat
- Satiety feelings --> hunger and satiety questionnaires
- Ghrelin response --> blood hormone level determination
- GLP-1 response --> blood hormone level determination
- Brain reward activity --> fMRI reward related areas
- Brain control activity --> fMRI control related areas
Secondary outcome
N.A.
Background summary
The previously popular Pringles jingle *once you pop, you just can*t stop*
perfectly describes a common belief of many that might emerge when eating
something good. In the current food affluent society, many people experience
occasions of not being able to stop eating, at least they think so. This belief
that one is not able to stop eating might be due to specific cognitions
(mindsets). In this innovative project, it is hypothesized that a mindset is
able to regulate the biological processing of food and in that way determines
actual consumption.
Participants will be randomly assigned to one of the two mindset conditions for
the first measurement. After a month, the participants will be measured in the
other mindset. In these conditions a control (even though you pop, you can
always stop) or a loss-of-control (once you pop, you just can*t stop) mindset
will be manipulated. The effect of these manipulated mindsets on brain
activation in reward and control areas, the release of the gut hormones ghrelin
and GLP-1, the desire to eat, the experience of control and satiety and actual
consumption will be measured.
It is hypothesized that the manipulated *once you pop, you just can*t stop*
mindset will induce biological responses that prepare for ongoing food intake,
even after eating, while the manipulated *even though you pop, you can always
stop* mindset will induce a biological and cognitive state of satiety,
independent from actual consumption. If the hypothesis is supported, these
findings might have large impact on the science of eating, health interventions
and consumer behaviour.
Study objective
The main goal of the current project is to study whether a mindset of perceived
control / loss of control over intake affects hormone release, brain reward
processing, desire to eat and actual consumption.
Study design
The current project is a single-blind randomized controlled trial comparing the
effect of two mindset conditions. First year female students will be recruited
at Maastricht University. The experiment consists of two sessions with a
duration of approximately 2 hours each.
Participants will be tested in two mindset conditions: (1) perceived loss of
control or (2) perceived control. These mindsets will be behavioral manipulated
by giving participants visual information and stimuli and the participants will
be asked to associate with these stimuli. After manipulating the participants*
beliefs, participants will be required to eat one piece of chocolate, and then
undergo a measurement session during which fMRI-scanning will be done to assess
activity in brain reward and control areas in response to pictures of
chocolate. It is made sure that the belief is kept salient during fMRI scanning
by repeatedly priming participants with the manipulated mindset during the
scanning period.
Furthermore, the effect of a perceived control / loss of control mindset will
also be examined on ghrelin and GLP-1 responses. Blood samples will be taken to
assess ghrelin and GLP-1 levels prior, during and after the scanning period.
Questionnaires on desire to eat and perceived control will be assessed using
visual analogue scales (VAS). There will be 5 time points where hormone levels
and desire to eat/perceived control VAS will be assessed. At the end of the
experiment a chocolate bogus taste test will be administered, to examine the
effect of a mindset on actual consumption. Ghrelin and GLP-1 will also be
measured after the chocolate-taste-test to study the hormonal post-intake
effect.
Intervention
The effect of two manipulated mindsets will be compared:
- Loss-of-control mindset
- Control mindset
Study burden and risks
The proposed study carries minimal risks and discomfort while the additional
information it significantly improves insight in the relationship between
cognitions (mindset) and biological responses related to food desires as well
as the actual response behaviour. The present study could provide innovative
direct and precise insight in relationships between gut hormone activity and
brain activity and their interactions. The participants will receive a
financial compensation (ยค100,00) in iris cheques after completing the study.
Universiteitssingel 40
Maastricht 6200 MD
NL
Universiteitssingel 40
Maastricht 6200 MD
NL
Listed location countries
Age
Inclusion criteria
female
first years' bachelor students (age between 18 - 25 years)
right handed
Score >70 mm on milk and/or dark chocolate liking rating
Exclusion criteria
- Not able to speak/write Dutch
- Standard MRI safety / contra-indication exclusion criteria; including: bodily metallic fragments/implants, pregnancy, claustrophobia, epilepsy
- anxious for needles/blood sampling
- Self-reported eating disorders
- Chronic diseases (e.g. diabetes mellitus)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL53894.068.15 |