To establish the changes in tumour diffusion hyperthermia induces in humans.
ID
Source
Brief title
Condition
- Cervix disorders (excl infections and inflammations)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Diffusion changes in the tumour.
Secondary outcome
Perfusion changes in the tumour.
Background summary
Currently used clinical treatment schedules are based on biological knowledge
of the late 1970s while recent discoveries have been made that suggest other
schedules may improve treatment efficacy. The improved understanding on the
hyperthermia interaction on tumour diffusion might lead to optimized scheduling
of the hyperthermia fractions with the radiotherapy fractions during the whole
radiotherapy + hyperthermia treatment series.
Study objective
To establish the changes in tumour diffusion hyperthermia induces in humans.
Study design
This trial is a prospective longitudinal within-subject study. Patients will
already be in the MR-scanner for the standard hyperthermia treatment. In two of
the five treatments, they will receive 3 extra diffusion weighted imaging (DWI)
scans.
Study burden and risks
No adverse of DWI-MRI scans are known. Patients will already be in an
MR-scanner as part of their standard treatment. Study burden consists of 16
minutes of extra time in the scanner.
Groene Hilledijk 301
Rotterdam 3075EA
NL
Groene Hilledijk 301
Rotterdam 3075EA
NL
Listed location countries
Age
Inclusion criteria
Patients with advanced cervical cancer who will receive MRI-guided hyperthermia as part of standard care. In addition, patients need to have a macroscopic tumour at the first hyperthermia treatment.
Exclusion criteria
Claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL62907.078.17 |