To generate a set of normal values in people over 60 that can be expected to have an normal immune system, in order to be able to interpret the immune system of eldery patients with repeated airway infections.
ID
Source
Brief title
Condition
- Immunodeficiency syndromes
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Generate a set of normal values for vaccin responses and T- and B-cel
subpopulations in peripheral blood in elderly people which can be expected to
have a normal immune system.
Secondary outcome
NA.
Background summary
For the interpretation of vaccin responses and the numbers of relevant
subpopulations of T-and B -cells in peripheral blood.of elderly patients with
repeated airway infections that are screened for an immune deficiency, we are
in need for normal values for this specific population. Currently we use normal
values that were obtained in young adults and we have reasons to believe that
the normal values of young adults aredifferent from the those in elderly > 60
years. To obtain normal values for this latter population we want to approach
patients that visit the outpatient clinic for chronci coughing, but have no
signs of an underlying immune deficiency, nor any other underlying disease that
may have an impact on the immune parameters under study.
Study objective
To generate a set of normal values in people over 60 that can be expected to
have an normal immune system, in order to be able to interpret the immune
system of eldery patients with repeated airway infections.
Study design
Observational study with intervention.
Intervention
Two vaccinations (tetanus and 23-serotypes containing pneumococcal
polysaccharide vaccin) and venapuncture.
Study burden and risks
There are no risks associated with study participations. Participants may
experience some discomfort at the site of application of the vaccins for a
maximum of 2 days. Futhermore an extra venapuncture may be necessary in case a
blood draw cannot be combined with one for regular blood tests.
Meibergdreef 9
Amsterdam-Zuidoost 1100 DD
NL
Meibergdreef 9
Amsterdam-Zuidoost 1100 DD
NL
Listed location countries
Age
Inclusion criteria
Cough e.c.i.
Exclusion criteria
use of immuunsupressives
infectious diseases such as RA, IBD or asthma in medical history or suspicion having one
HIV infection
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL62634.018.17 |