Hypothesis: Early life stress is associated with increased caloric intake and subsequent obesity in later life, which may be mediated by (a combination of) decreased neural cognitive control over food intake, decreased neural food reward…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
obesitas
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Measures per key objective
1. Caloric intake: calculated from Food Frequency Questionnaire.
2. a. Neural cognitive control over food intake: we will compare fMRI responses
to a food-based Go-No-Go test to measure impulsivity.
b. Neural food reward responsiveness: we will compare fMRI responses
between exposure groups in response to receiving cholate milk versus a
tasteless solution.
c. Satiety: satiety responsiveness based on Child Eating Behaviour
Questionnaire (CEBQ); leptin and ghrelin levels to be assessed from saliva
samples .
d. Emotional eating: quantity of food intake in response to stresstask
during fMRI protocol; Dutch Eating Behaviour Questionnaire.
Perceived stress: in response to stress and based on Perceived Stress
Questionnaire.
e. Food preference: food cue responsiveness based on CEBQ .
f. Cortisol activity: cortisol day curves from saliva (4 samples) and in
response to stresstask during fMRI protocol (4 saliva samples); cortisol from
hair sample (to measure stress over longer period of time).
3. Mental health: total score on Strengths and Difficulties Questionnaire (SDQ)
and on Children*s Revised Impact of Event Scale (CRIES-13) administered at
11-12.
Secondary outcome
Covariates/confounders: maternal characteristics, birth outcomes,
socio-economic status, ethnicity, physical activity, sedentary behaviour and
sleep.
Background summary
The ABCD - Amsterdam Born Children and their Development - study is a
longitudinal multi-ethnic birth cohort examining the association between
maternal lifestyle, medical, psychosocial and environmental conditions during
pregnancy and children*s health at birth as well as in later life. Recently, at
the age of 11-12 years, data was collected on physical measurements including
anthropometry, cardiovascular function, metabolic profile, genetic
predisposition and mental health.
In the present study, we aim to unravel the potential pathways underlying the
association between early life stress (ELS) and increased risk for obesity. For
this purpose, we will select a subsample of the ABCD cohort based on maternal
anxiety scores during pregnancy, on maternal obesity before pregnancy and on
CRIES score of the children at age 11-12 years.
Study objective
Hypothesis: Early life stress is associated with increased caloric intake and
subsequent obesity in later life, which may be mediated by (a combination of)
decreased neural cognitive control over food intake, decreased neural food
reward responsiveness, decreased satiety responses, increased emotional eating,
preference for comfort food or altered cortisol activity.
The objectives of the subsample study of the present ABCD-subsample study are:
(i) to investigate the association between ELS (prenatal stress, maternal
obesity and childhood stress) and caloric intake
(ii) to test a number of processes that could underlie the association between
ELS and increased risk for obesity, including:
a) neural cognitive control over food intake
b) neural food reward responsiveness
c) satiety
d) emotional eating in response to stress
e) food preferences
f) cortisol activity
(iii) to investigate mental health problems as potential moderator or mediator
of the association between ELS and the tested processes.
Study design
The ABCD-study is a multi-ethnic prospective birth cohort study. For the
present study, a subsample will be selected.
Study burden and risks
In the current study no adverse/serious adverse events are expected. The study
imposes no risks to the subjects. Saliva samples and hair samples will be taken
for cortisol, leptin and ghrelin measurements,. This is painless and safe.
Furthermore, fMRI scanning will be performed. A small percentage of
participants may experience claustrophobia or anxiety during scanning. It will
therefore be stressed that the procedure can be stopped any moment. A short
stress task will be performed based on an existing protocol (Montreal Imaging
Stress Task) that has been performed in this age group numerous times and is
safe. There is no direct benefit of this study to the participants.
Participants will receive a small present for participating. The procedure will
take 3 hours maximum and burden will be kept as low as possible.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
The ABCD- study cohort consists of 12-13 year old children whose mothers have been participating in the ABCD-study since the start of antenatal care during pregnancy. For the present study a subsample will be selected consisting of:
• Children whose mothers scored in the 90st percentile of the State trait Anxiety Inventory during pregnancy (n=30)
• Children whose mothers were in the 90st percentile of BMI before pregnancy (n=30)
• Children who scored above the clinical cut-off score on the Children*s Revised Impact of Event Scale (CRIES) at the age of 11-12 years (n=30).
• A control group of children who do not fulfil the above criteria (n=30).
Exclusion criteria
Children born to mothers who did not participate in the ABCD-study during phase 1. Additionally, of the children born to mothers who did participate in the ABCD-study, all multiples and those whose parents did not give informed consent for the health check will be excluded. Additionally those children who do not give consent will be excluded.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL61777.018.17 |