With this study we will evaluate the following hypothesis: Does acute systemic inflammation induces plaque instability and could it be repsonsible for the elevated risk of cardiovascular events. Eventually this study can contribute to the knowledge…
ID
Source
Brief title
Condition
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
FDG-tracer uptake in the vessel wall
Secondary outcome
Markers of systemic inflammation in the blood
Background summary
Observational studies confirm that the risk for cardiovasculair events is
elevated in the weeks after conditons of systemic inflammation, such as majeur
orthopedic surgery and sepsis. It is unknown what is the reason for this
attributed risk, athough It has been suggested that inflammation enhances
atherosclerosis.
Study objective
With this study we will evaluate the following hypothesis: Does acute systemic
inflammation induces plaque instability and could it be repsonsible for the
elevated risk of cardiovascular events. Eventually this study can contribute to
the knowledge of infarction and stroke and could help to reduce the incidence.
Study design
To eveluate the effect of pneumonia and major surgery on atherosclerosis we
perform scans of the vessels. We compare trace uptake in the atherosclerotic
plaques during a periode of systemic inflammation and during a periode without
systemic inflammation.
Study burden and risks
The risk is considered intermediate. There is a small change of a severe
complications: malignant tumor as a consequence of the radiation
boelelaan 1118
Amsterdam 1081 HZ
NL
boelelaan 1118
Amsterdam 1081 HZ
NL
Listed location countries
Age
Inclusion criteria
Admitted for pneumonia or being scheduled for total knee replacement or total hip replacement.
A calculated 10 years risk of fatal cardiovascular disease of >= 10 % in the SCORE table
Age > 50 years
Exclusion criteria
Unable to remain supine for at least 60 minutes
Pneumonia patients being too ill, as considered by the treating physician
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54345.029.15 |