Explore difference in perforating artery pulsatility index between two patients groups with small vessel disease (history of lacunar infarct and deeply located haemorrhage) and healthy controls.
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Difference in pulsatility of cerebral perforating arteries between patients and
healthy controls.
Secondary outcome
N.A.
Background summary
Recently, we developed a novel and promising MRI technique that assesses the
pulsatile blood flow velocity in small cerebral perforating arteries. Increased
blood flow pulsation is hypothesized to be in the causal pathway of many
cerebrovascular pathologies of the smaller vessels. Our simulations suggest
that, with 7T MRI, we can measure the blood flow pulsatility index (PI) in
vessels with a diameter of 80 microns and larger. Until now, doppler ultrasound
and lower field MRI have been used to measure PI, but can only do so up to the
large intracerebral vessels. Many cerebrovascular pathologies arise at the
level of much smaller arteries. Therefore, it is important to investigate the
new small vessel PI marker in relevant patient groups. We will investigate two
patient groups with cerebrovascular disease of small intracerebral arteries.
The first patient group we will study consists of patients with lacunar
infarction (which are known to have a different pulsatility index (PI) of the
larger vessels) and the second group consists of patients with a history of
deep hemorrhages (which are associated with hypertension, and thus to changes
in PI).
Study objective
Explore difference in perforating artery pulsatility index between two patients
groups with small vessel disease (history of lacunar infarct and deeply located
haemorrhage) and healthy controls.
Study design
Because pulsatility in perforating cerebral arteries has not been studied
before, this will be an explorative observational study. The study will have a
case control design with two patient groups and a control group.
Study burden and risks
Negligible low risk study with low burden.
Heidelberglaan 100
Utrecht 3508 GA
NL
Heidelberglaan 100
Utrecht 3508 GA
NL
Listed location countries
Age
Inclusion criteria
Lacunar infarction group:
- Clinical lacunar stroke confirmed by imaging, in the last 5 years.
Deep ICH group:
- Deep spontaneous ICH, compatible with so-called hypertensive hemorrhage or ICH due to SVD, confirmed by imaging, in the last 5 years.
Healthy control group:
- No history of stroke, transient ischemic attack or cognitive impairment.
Exclusion criteria
All groups:
- WHO performance status score * 2. (independent mobility and living)
- Currently hospitalized.
- MRI contraindications per clinical practice, such as (possible) pregnancy and metal or electronic implants not compatible with (7T) MRI.
Control group:
- When study images for a control subject as a chance finding show confluent white matter hyperintensities (Fazekas scale > 2), lacunes or ICH the control will be excluded and replaced.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL52997.041.15 |