The aim of the project is to examine the association between clinical, environmental and genetic characteristics of the recipient of erythrocyte transfusions and the risk or resistance to immunization against erythrocyte alloantigens that he/she was…
ID
Source
Brief title
Risk Factors for Alloimmunisation by red blood Cell Transfusions
Condition
- Haemolyses and related conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Our case-control study will quantify and characterize clinical risk factors of
patients and conditions for transfusion associated alloimmunisation. Patients
will be given a questionnaire to assess environmental and life style risk
factors.
Blood sampling (upon informed consent) and buccal mucosal swabs will be carried
out to determine genetic variation of immunization against red blood cell
antigens.
Secondary outcome
-na-
Background summary
Alloantibodies can lead to serious clinical consequences and logistic problems
like obtaining properly and timely matched blood for the patients who do
develop these antibodies. Prevention of such serious events is possible by
extended matching and typing of donor*s blood against the patient*s for all the
possible antigens, but this process is cumbersome and costly. Identifying a
high risk group will be a feasible first target for advanced matching a big
step forward, and the aim of our study.
Study objective
The aim of the project is to examine the association between clinical,
environmental and genetic characteristics of the recipient of erythrocyte
transfusions and the risk or resistance to immunization against erythrocyte
alloantigens that he/she was exposed to during that transfusion episode.
Study design
A retrospective case- cohort study will be performed.
Study burden and risks
Burden: the patients are asked to answer a short Questionnaire and one time
Blood taking (= 25ml./ participant) or donation of 3 buccal musocal swabs.
Risk: Negligible, trained personnel involved in blood taking and handling.
Albinusdreef 2
Leiden 2333 ZA
NL
Albinusdreef 2
Leiden 2333 ZA
NL
Listed location countries
Age
Inclusion criteria
- Patients for the first time diagnosed with transfusion dependent red blood cell alloantibodies (=patients who received transfusions before detection of alloantibodies).
- Patients who have been transfused, yet did not form red cell alloantibodies afterwards
Exclusion criteria
- Age below 18 years
- Patients with transfusions prior to the start of study inclusion period.
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29563.058.09 |