The aim of this study is to evaluate the quality of the cartilage of repaired defects 20-25 years after perichondrium transplantation (PT) or autologous chondrocyte translantation (ACT). Secondary objectives are to review the functionality and pain…
ID
Source
Brief title
Condition
- Tendon, ligament and cartilage disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the difference of cartilage quality between the PT
and ACT group assessed by 7T MRI.
Secondary outcome
1. Quality of cartilage transplant compared to radiographic Kellgren-Lawrence
OA grade.
2. Quality of cartilage transplant compared to functionality of the treated
knee; KOOS, ICRS-score
3. Quality of cartilage transplant compared to level of pain in the treated
knee; VAS-score
Background summary
Knee injuries are extremely common and are often seen in otherwise healthy,
active patients. The traumatic force on the knee often results in focal
cartilage defects of the weight-bearing articular surfaces. After traumatic
lesions, osteoarthritis is one of the most prevalent chronic diseases and a
significant socioeconomic burden on the population. Accurate detection of
cartilage lesions is important to identify patients who may benefit from early
surgical intervention. Different treatment options have been available in the
last decades. There are only few study results with long-term follow-up of
patients, treated with these techniques.
The aim of this study is to compare the long-term results in the quality of
repaired articular cartilage between patients treated with PT and ACT. Because
7 Tesla (7T) MR imaging reveals promising results, it is a good choice to
evaluate the cartilage structure.
Study objective
The aim of this study is to evaluate the quality of the cartilage of repaired
defects 20-25 years after perichondrium transplantation (PT) or autologous
chondrocyte translantation (ACT). Secondary objectives are to review the
functionality and pain of the operated knee compared to the quality of the
cartilage.
Study design
This is an observational study.
Study burden and risks
Patients from the PT and ACT database are good candidates to assess the
cartilage quality after 2 different types of cartilage repair surgery. Physical
examination and three questionnaires (KOOS, IKDC-2000 and SF-36) have already
been done for routine clinical follow-up (niet-WMO: METC-13-4-038). The only
effort for the patient is to visit the scannexus lab for a 7T MRI scan of
approximately 45 minutes. The patients get a more detailed examination of their
knee by a high resolution MRI. The risks of a 7T MRI scan are negligible and no
side effects are expected from the scan.
P. Debyelaan 25
Maastricht 6229 HX
NL
P. Debyelaan 25
Maastricht 6229 HX
NL
Listed location countries
Age
Inclusion criteria
Age > 18 years old
Underwent perichondrial tranplantation in MUMC or autologous chondrocyte transplantation in Sweden between 1986 and 1996.
Exclusion criteria
- Knee arthroplasty in area of transplant (i.e. total-, hemi- knee arthroplasty)
- Major surgery of transplant in the knee (e.g. patellectomy, microfracture)
- Osteoartritis (grade 4 kellgren and Lawrence scale)
- Systemic diseases (e.g. DM II, Rheumatoid arthritis)
- Not able to undergo MRI scanning (metal objects in body, tattoo, etc.)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL48277.068.14 |