To quantify the effects of several factors on muscle relaxation of the finger flexors measured with TMS. These factors are contraction strength (as a percentage of the maximum), stimulus intensity, muscle temperature, and position of stimulator coil…
ID
Source
Brief title
Condition
- Muscle disorders
- Neuromuscular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Peak relaxation rate normalized to force prior to relaxation
- Half-relaxation time: the time needed for force to drop from 100% to 50% of
maximal force
Secondary outcome
- Maximal force of fingerflexors
- Percentage force decrease in first 150ms after the TMS pulse.
- Duration of the silent period
Background summary
Transcranial magnetic stimulation (TMS) can induce involuntary muscle
relaxation by abruptly interrupting corticospinal drive to the muscle (~200ms).
Slow muscle relaxation might be indicative for differnent myopathies. We have
previously shown a slow muscle relaxation in patients with Brody disease. The
current study is focused on optimising the set-up for measuring muscle
relaxation using TMS. The final goal of these studies is to develop a screening
test to determine which patients with positive muscle phenomena might be
suffering from a muscle disease.
Study objective
To quantify the effects of several factors on muscle relaxation of the finger
flexors measured with TMS. These factors are contraction strength (as a
percentage of the maximum), stimulus intensity, muscle temperature, and
position of stimulator coil. The primary outcome measures are normalised peak
relaxation rate and relaxation time. Another objective is to evaluate the
interday reproducibility of TMS-induced muscle relaxation and compare it with
voluntary relaxation.
Study design
Explorative research to determine the influence of contraction strength,
temperature, stimulus position and intensity on the relaxation profile of
finger flexor muscles. Furthermore we want to evaluate the interday
reproducibility of TMS-induced muscle relaxation and compare it with voluntary
relaxation.
Study burden and risks
Three visits to our lab of 45-60 minutes. There can be slight discomfort from
the TMS (mild headache in 2-4% of subjects).
Reinier Postlaan 4
Nijmegen 6525 GC
NL
Reinier Postlaan 4
Nijmegen 6525 GC
NL
Listed location countries
Age
Inclusion criteria
Age of 20 to 60 years old
Exclusion criteria
Age <18
Pregnancy
Serious head trauma or brain surgery
Diagnosis of any neuromuscular disorder
Large or ferromagnetic metal parts in the head Implanted cardiac pacemaker or neurostimulator Epilepsy, convulsion or seizure
Use of medication that can influence muscle relaxation or cortical excitability
Duration of silent period <180ms despite using maximal stimulator intensity
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL60169.091.16 |