To investigate contributions of parietal theta oscillations in recollection processes.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Fundamenteel onderzoek bij gezonde vrijwilligers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Investigating whether activity in the theta-band frequency is necessary for
recollection-related processes in memory.
Secondary outcome
Not applicable
Background summary
Neural oscillations in the theta-band frequency range have been associated with
memory processes, specifically recollection related processes. However, most
studies were correlational in nature, so to what extend theta oscillations are
necessary for recollection-related processes remains unknown. The aim of this
study is to shed more light on this issue. We will apply online 3.5 Hz
transcranial alternating current stimulation (tACS) over parietal cortices to
alter recollection processes. Before stimulation participants will encode
words, which will be retrieved in a recognition test while receiving tACS
stimulation. It is hypothesized that theta tACS stimulation will facilitate
recollection processes. The study will enhance our understanding of the role of
the theta oscillations in memory processes.
Study objective
To investigate contributions of parietal theta oscillations in recollection
processes.
Study design
A randomized double-blind controlled within-subject design. The experiment
consists of three test sessions on three separate days. In the test sessions,
participants will perform a recognition memory task. In one of the three test
sessions, participants will receive bilateral 3.5 Hz tACS, and in one of three
test sessions, participants will receive bilateral 8 Hz tACS. Sham tACS will
serve as the active control condition, and will be administered during the
remaining session. Test sessions will be randomized and counterbalanced across
participants.
Intervention
Transcranial alternating current stimulation (tACS) will be by a battery-driven
constant DC current stimulator (Eldith DC Stimulator (CE 0118), Ilmenau) using
a pair of electrodes (25 cm^2) over the left and right parietal hemisphere and
a reference electrode (100 cm^2) over the vertex, on three separate occasions.
Participants will receive bilateral 3.5 Hz tACS (1 mA/25 cm^2, 30 min) during
one session, bilateral 8 Hz tACS (1 mA/25 cm2, 30 min) during one session, and
bilateral sham tACS (0 mA/25 cm^2, 30 min) during one session.
Study burden and risks
The currently proposed tACS procedure does not carry any significant risks.
Safety guidelines as acknowledged by the International Federation of Clinical
Neurophysiology will be followed strictly. Potential side-effects of tACS are
muscle tension and headache. These are generally mild discomforts that respond
promptly to common analgesics. Volunteers can withdraw from the study at any
given time and there are no direct benefits for the participants.
Montessorilaan 3
Nijmegen 6525 HR
NL
Montessorilaan 3
Nijmegen 6525 HR
NL
Listed location countries
Age
Inclusion criteria
Between 18-35 years of age years, right-handed, non-smoking, normal or corrected-to-normal vision, Dutch as a native language
Exclusion criteria
Skin disease, metal in cranium, use of psychotropic drugs, including cannabis, XTC, amphetamines and cocaine, epilepsy or family history ofepilepsy, history of closed-head injury, history of neurological or psychiatric disorders, medication use (i.e., benzodiazepines, antidepressants and neuroleptica), cardiac pacemaker, electronic hearing devices, pregnancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL61216.091.17 |