Structural and functional measurements for glaucoma detection and monitoring in early, moderate and advanced glaucoma

The use of structural measurements from imaging devices and functional
measurements from perimetry for the detection and monitoring of glaucoma
remains a topic of great interest in current scientific research. There is no
consensus on what measurement technique or combination of techniques is best
used for the detection of glaucoma and the monitoring of the disease in the
early, moderate and advanced stages of glaucoma. This is partly because
comparing these different measurements techniques in the different stages of
glaucoma is difficult because they measure different quantities, expressed by
different units. Furthermore, there is sufficient evidence that the correlation
between structural and functional measurements is poor. This poor correlation
has several causes, such as measurement noise and differences in measurement
variability and bandwidth between the various measurements techniques in the
different stages of glaucoma. A comparison of the performance of each
measurement technique for the different stages of glaucoma would enable us to
select the optimal technique for both the detection and monitoring of glaucoma,
and thereby further improve our clinical management of glaucoma.

to evaluate the functional and structural measurements for glaucoma detection
and monitoring at different stages of the disease.

Observational cross-sectional and longitudinal cohort-study

Imaging with commercially available low-luminance ophthalmic camera*s and
scanning devices, functional testing with standard perimetry (usual care),
measurements of intraocular pressure (usual care). Added burden will be 0.5-1.5
hour per annum for patients with glaucoma and 1.5-2.0 hours per annum for
healthy controls. No risks.