To demonstrate a direct relation between the cerebellum and electrophysiological and behavioural indices of response inhibition and error processing in healthy volunteers.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Onderzoek bij gezonde vrijwillgers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
EEG: Error-related negativity (ERN) and feedback-related negativity (FRN) brain
potentials associated with response inhibition and error processing. Behaviour:
% Error-rate and post-error slowing of reaction times.
Secondary outcome
not applicable
Background summary
Growing evidence point to a role of the cerebellum in non-motor related
executive functions related to response inhibition and error processing to
support frontal cortical executive functions. However, the available evidence
is correlational and based on a limited number of cerebellar patient studies.
The examine the direct involvement of the cerebellum in action monitoring and
error processing we want to use an established method of transcranial direct
stimulation to modulated cerebellar activity to examine its effects on
electro-cortical potentials as measured with the electroencephalogram (EEG) and
behaviour.
Study objective
To demonstrate a direct relation between the cerebellum and
electrophysiological and behavioural indices of response inhibition and error
processing in healthy volunteers.
Study design
Double-blind placebo controlled cross-over design.
Intervention
Transcranial direct current stimulation (tDCS) will be delivered by a
battery-driven electric current stimulator (Eldith DC Stimulator (CE 0118),
Ilmenau) using a pair of electrodes: (1) cathodal electrode over the medial
cerebellum (35 cm²); (2) anodal electrode over the right deltoid muscle (25
cm²). Stimulation will be delivered for 20 minutes during an inhibition
response task. Stimulation comprises either: (1) cathodal tDCS (2 mA); and (2)
placebo (sham) tDCS (0 mA).
Study burden and risks
The currently proposed tDCS procedure and experiment does not carry any
significant risks. Stimulation will be performed in line with the Standard
Operating Procedure Non-Invasive Brain Stimulation of the Donders Institute for
Brain, Cognition and Behaviour. Potential side-effects of tDCS are itching or
burning sensations on the under the electrodes, light headache and/or fatigue.
These are mild discomforts that respond promptly to common analgesics.
Volunteers can withdraw from the study at any given time and there are no
direct benefits for the participants. The novel insights will broaden our
fundamental understanding of the cerebellum
Montessorilaan 3
Nijmegen 6525HR
NL
Montessorilaan 3
Nijmegen 6525HR
NL
Listed location countries
Age
Inclusion criteria
Between 18-35 years of age years; Right-handed; Non-smoking; Normal or corrected-to-normal vision; Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements.
Exclusion criteria
1) Average use of more than 3 alcoholic beverages daily; (2) Use of psychotropic medication or recreational drugs; (3) Skin disease; (4) Pregnancy; (5) Serious head trauma or brain surgery; (6) Neurological or psychiatric disorders; (7) Large or ferromagnetic metal parts in the head (except for a dental wire); (8) Implanted cardiac pacemaker or neurostimulator; (9) Participation in a NBS study in the past 28 days; (10) Previous participation in 10 or more NBS studies.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL60322.091.17 |