The primary objective of this study is to evaluate upper extremity and trunk function in persons with SMA in different stages of the disease using 3D movement analysis, muscle force measurements, surface electromyography and activity scales. The…
ID
Source
Brief title
Condition
- Neurological disorders congenital
- Neuromuscular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The most important outcome measures are: maximal muscle force, active range of
motion, muscle activity measured with surface electromyography and trunk
impairment score.
Secondary outcome
Secundary outcome measures are: passieve range of motion, trunk balance and
stability, performance of upper limb scale, 9-hole peg test, Timed_TIHM en
Brooke scale.
Background summary
Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA) are
progressive neuromuscular disorders which affects arm, trunk and hand function.
Weakened arm and trunk function has a huge impact on independence and quality
of life, especially when wheelchair confined. As a result new tools are needed
that can support arm and trunk function. An arm exoskeleton might be an
effective method to support the arms of people with DMD and SMA, and thereby
improve daily functioning. However for further development of such an
exoskeleton (which has been developed for people with DMD in a previous study),
more knowledge is needed on the arm, trunk and hand function of people with
SMA (this knowledge has already been obtained in DMD patients). In addition, an
improved version of the exoskeleton needs to be evaluated in both DMD and SMA
patients.
Study objective
The primary objective of this study is to evaluate upper extremity and trunk
function in persons with SMA in different stages of the disease using 3D
movement analysis, muscle force measurements, surface electromyography and
activity scales. The secondary objective is further development and evaluation
of the passive A-Gear in people with DMD and SMA, using both home-based and
lab-based measurements.
Study design
Explorative cross-sectional study
Study burden and risks
The burden and risks associated with participation are small. The movements
that are measured are movements that are also performed in daily living and the
movements will not be forced. Furthermore, the measurement protocol is not
invasive.
Reinier postlaan 4
Nijmegen 6500 HB
NL
Reinier postlaan 4
Nijmegen 6500 HB
NL
Listed location countries
Age
Inclusion criteria
DNA established diagnosis of DMD or SMA
Brooke scale 1 to 4
Ambuland and non-ambulant
Exclusion criteria
Participants younger than 7 years
Other disabling diseases influencing upper extremity function
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL58988.091.16 |