To identify determinants that explain phenotypic variability in MS while excluding age as a confounding factor and to detect determinants which may guide intervention strategies and predict the disease course in MS.
ID
Source
Brief title
Condition
- Demyelinating disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Clinical status (Expanded Disability Status Scale (EDSS), Multiple Sclerosis
Functional Composite (MSFC)), exposure to various determinants, comorbidity,
quality of life (QoL), cognitive status (neurpsychological evaluation (NPO)),
imaging parameters (magnetic resonance imaging (MRI), magnetoencephalography
(MEG), optical coherence tomography (OCT) and eyetracker) and Bone Mineral
Density (BMD) measurement.
Secondary outcome
Not applicable.
Background summary
Detecting determinants of disease variability is pivotal to guide the search
for effective therapies and optimize patient care in multiple sclerosis (MS).
One of the most important confounders when studying the disease course in MS is
age. We plan to recruit all people with MS born in The Netherlands in 1966,
which will result in an unbiased population based cohort in which age cannot be
a confounder. This cohort will be subjected to extensive examinations of a wide
array of potential determinants and outcome measures.
Study objective
To identify determinants that explain phenotypic variability in MS while
excluding age as a confounding factor and to detect determinants which may
guide intervention strategies and predict the disease course in MS.
Study design
Population-based cross-sectional study. All participants will be asked be
invited to the VUmc for a 1 day program in which all data will be collected.
Total duration of the study will be 3 years.
Study burden and risks
The burden of participation consists of a 1-day visit to the VUmc
(approximately 7 hours). During this day participants will undergo a series of
measurements (clinical scales, NPO, MRI, MEG, OCT, eye movements) and a blood,
urine and feces sample will be collected. After their visit, all participants
are asked to fill in a selection of questionnaires at home (approximately 1
hour). There is no direct benefit for participants of this study.
De Boelelaan 1117
Amsterdam 1081 HV
NL
De Boelelaan 1117
Amsterdam 1081 HV
NL
Listed location countries
Age
Inclusion criteria
- Born in 1966 in the Netherlands
- Currently living in the Netherlands
- Diagnosis of MS
Exclusion criteria
Patients: none
Controls: comorbidity that interferes with participation in this study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL61310.029.17 |