We aim to i) characterize flow patterns and ii) assess energetic properties in the LV of patients with LBBB (with and without heart failure) and iii) compare findings with those in healthy volunteers.
ID
Source
Brief title
Condition
- Cardiac arrhythmias
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Description and quantification of various intracavitary LV blood flow
parameters (such as vortex flow patterns, vortex rings, vortex formation time,
kinetic energy, energy dissipation).
Secondary outcome
Not applicable.
Background summary
Blood flow in the healthy human heart is characterized by the presence of
vortices. These ring-shaped regions of rotating flow motion improve the
efficiency of LV filling, preserve kinetic energy and enhance LV ejection. It
is unknown to what extent conduction disorders like left bundle branch block
(LBBB) influence intracardiac blood flow. Hypothetically, the sequential
myocardial contraction and relaxation in LBBB can cause disturbance of normal
LV vortex formation, hereby causing rapid dissipation of kinetic energy and
impairment of LV efficiency. Recent developments of non-invasive cardiovascular
imaging techniques have allowed for in-depth analysis of vortex biology in the
heart. Four-dimensional flow magnetic resonance (4D flow MR) imaging is an
emerging flow imaging technique that is capable of visualizing blood flow in a
three-dimensional volume during all phases of the cardiac cycle. The purpose of
this study is to use 4D flow MR for the investigation of LV blood flow patterns
and LV efficiency in patients with LBBB.
Study objective
We aim to i) characterize flow patterns and ii) assess energetic properties in
the LV of patients with LBBB (with and without heart failure) and iii) compare
findings with those in healthy volunteers.
Study design
This study is designed as an observational (cross-sectional) study conducted at
the Maastricht University Medical Center (MUMC+).
Study burden and risks
This is a descriptive study that will not interfere with routine medical
treatment. Participants will undergo MR examination (one session of
approximately 1 hour). MR imaging techniques are considered to be very safe.
The proposed MRI scan protocols are routinely used and thus non-experimental.
4D flow MR uses the intrinsic magnetic properties of the human body and does
not require the use of a contrast agent. Participants are not subject to
ionizing radiation. Briefly, participation in this study is considered to be of
low risk and low burden. Study results are expected to further unravel
physiological consequences of LBBB, which may contribute to a better
understanding of the disease mechanisms of LBBB in e.g. heart failure.
P. Debyelaan 25
Maastricht 6229 HX
NL
P. Debyelaan 25
Maastricht 6229 HX
NL
Listed location countries
Age
Inclusion criteria
- Age >18 years old.
- Meets criteria for definition of left bundle branch block (except for healthy volunteers).
- Mentally competent.
- Willing to provide written informed consent.
Exclusion criteria
- Angina or suspicion of acute cardiac ischemia.
- Documentation or echocardiographic signs of prior myocardial infarction.
- Atrial fibrillation or tachycardia >100 bpm.
- Prior cardiac/aortic surgery.
- Overt signs/symptoms of heart failure.
- Congenital/genetic heart disease.
- Moderate/severe valvular disease.
- Contra-indication for MR examination (such as pacemaker, neuro-stimulator etc.).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL59828.068.16 |