The primary objective of the study is to determine the effects of age on corticomotor excitability of five shoulder muscles (anterior deltoid, upper trapezius, lower trapezius, serratus anterior, erector spinae). The secondary objective is to…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Gezonde jongeren en ouderen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the corticomotor excitability of the five shoulder
muscles measured by TMS in the form of a recruitment curve
Secondary outcome
The secondary study parameter is the weight of the arm, forearm and the hand.
Background summary
The ability to perform activities of daily living (ADL) contributes to older
adults* quality of life. Incidence of shoulder dysfunction increases with age
and interferes with the execution of ADLs that involve the upper extremity,
thus compromising quality of life. Therefore it is important to understand the
mechanisms involved in age-related shoulder dysfunction. One explanation for
decreased shoulder function in older adults could be the related evolution of
impairment in shoulder joint control caused by a decline in sensorimotor
control and function. There is sporadic evidence for impaired shoulder muscle
control in old adults demonstrated by surface electromyography (EMG) that
measures muscle activity. While surface EMG provides some insights into the
timing and magnitude of muscle contraction, this method provides limited or no
information on the motor cortical and corticospinal control of voluntary
shoulder movements. Transcranial Magnetic Stimulation (TMS) can overcome such
shortcomings. Previous studies only examined the deltoid and the supraspinatus
muscles using TMS, but the results were inconsistent with many other studies
examining the corticomotor excitability in the hand. Given that in previous
studies only examined the deltoid and the supraspinatus, there is still a gap
in the knowledge concerning the link between aging and corticomotor
excitability of other shoulder muscles. Therefore, this study will include
examination of essential shoulder muscle mobilizers (deltoid, trapezius,
serratus anterior) and a muscle that stabilizes the trunk (postural erector
spinae).
Study objective
The primary objective of the study is to determine the effects of age on
corticomotor excitability of five shoulder muscles (anterior deltoid, upper
trapezius, lower trapezius, serratus anterior, erector spinae). The secondary
objective is to determine the effect of arm support on the corticomotor
excitability of these muscles in young and old adults.
Study design
The design of the study will be a cross-sectional repeated measures design with
3 conditions. Responses to TMS will be recorded in the form of a recruitment
curve from the five muscles under the conditions. Shoulder abducted to 90°
relative to the arm: 1. Fully supported, 2. 50% supported, and 3. Unsupported.
Study burden and risks
Participants will visit the Center for Human Movement Sciences once for a
session that will take approximately one and a half hour. TMS is
non-therapeutic and the measurements are non-invasive. TMS could cause slight
discomfort lasting less than a second on the scalp near the coil. Moreover it
can cause some twitching of the muscles, the face and the jaw. This can be
unpleasant and surprising, but it is not painful. There are no known long-term
risks of TMS.
Antonius Deusinglaan 1
Groningen 9713 AV
NL
Antonius Deusinglaan 1
Groningen 9713 AV
NL
Listed location countries
Age
Inclusion criteria
Healthy, right-handed, aged 18 to 35 or 65 to 85
Exclusion criteria
Diagnosed pathologies that could interfere with the measurement results
Presence of pain in the shoulder
History of severe trauma of the shoulder within the previous two years (e.g. fracture, luxation)
Neurological disorders
Pregnancy
A history of epilepsy
Use of a pacemaker and metal in the brain/skull
Use of medication that can have an influence on the measurement
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL59272.042.16 |
| Other | UMCG research register: 201600329 |