To compare histopathology and immunofluorescence expression of keratins, epidermal barrier proteins and adhesion molecules in hyperkeratotic hand eczema (lesional skin) and non lesional skin of the palms in patients, compared to healthy individuals…
ID
Source
Brief title
Condition
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To compare the immunofluorescence profile of different keratin proteins,
epidermal barrier proteins and adhesion molecules in the skin of patients with
hyperkeratotic hand eczema with healthy controls
Secondary outcome
- To compare lesional with non lesional skin of the palms of hyperkeratotic
hand eczema patients
- To describe the histopathology of hyperkeratotic hand eczema
- To describe the ultrastructure and expression of desmosomal components of
hyperkeratotic hand eczema compared to healthy controls
Background summary
Hand eczema is a common skin disease with a high socioeconomic impact. It has
an estimated 1-year prevalence of up to 10% and is considered to be the most
common occupational skin disease, leading to prolonged sick leave or a change
of job. It has also a high burden of disease due to the visibility and the
social importance of the hands. Different hand eczema subtypes exist.
Hyperkeratotic hand eczema is a well characterized morphological subtype of
hand eczema. Typical are sharply demarcated areas of hyperkeratosis on the
palms (and frequently on the soles), as are painful fissures. Vesicles are
absent. The pathophysiology of hyperkeratotic palmar eczema has not been
elucidated.
Study objective
To compare histopathology and immunofluorescence expression of keratins,
epidermal barrier proteins and adhesion molecules in hyperkeratotic hand eczema
(lesional skin) and non lesional skin of the palms in patients, compared to
healthy individuals.
Study design
Observational case control study
Study burden and risks
Skin of healthy volunteers and patients with hyperkeratotic hand eczema will be
obtained by punch biopsies under local anesthesia. It is a generally safe
procedure with minimal burden to the patient. Possible complications of
bruising, bleeding, infection and scarring rarely occur. Both participants in
the case group and participants in the control group need to visit only once.
Patients will be compensated for their costs and will additionally receive a
compensation for participating in the study.
Hanzeplein 1
Groningen 9700 RB
NL
Hanzeplein 1
Groningen 9700 RB
NL
Listed location countries
Age
Inclusion criteria
- Written informed consent.
- >=18 years old.
- Hyperkeratotic hand eczema as defined by the Danish Contact Dermatitis Group
- No concomitant diagnose of atopic dermatitis (current)
Exclusion criteria
• Immunosuppressive or immunomodulatory treatment within the last 4 weeks
• UV radiation therapy within 4 weeks before biopsy
• Active bacterial, fungal or viral infection of the hands
• Other skin diseases of the hands
• Proven contact sensitization with clinical relevance to the hands, in which exposure to allergens is not avoided
• History of psoriasis or psoriasis lesions elsewhere on the body
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL65563.042.18 |