To assess whether an association exists between level of sIL-2R and disease severity in Complex Regional Pain Syndrome.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Complex Regionaal Pijnsyndroom
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are the blood sIL-2R level and CRPS severity score in
patients with CRPS.
Secondary outcome
Not applicable.
Background summary
Soluble interleukine-2 receptor levels have been shown to be correlated with
disease severity in diseases such as sarcoidosis and rheumatoid arthritis.
Recently, this marker has been found to be elevated in Complex Regional Pain
Syndrome (CRPS) patients vs healthy controls. In this study we aim to
investigate whether an association exists between level of the sIL-2R in CRPS
patients and CRPS disease severity.
Study objective
To assess whether an association exists between level of sIL-2R and disease
severity in Complex Regional Pain Syndrome.
Study design
Cross sectional cohort study.
Study burden and risks
This study carries a negligible risk related to venepuncture. Only one tube of
blood is drawn for analysis of sIL-2R level. There is no direct benefit for
participants. This study is conducted during the patient*s routine visit to the
outpatient clinic of the Center for Pain Medicine. The results of this study
could lead to the use of the sIL-2R as a marker for disease severity in CRPS.
Dr. Molenwaterplein 40
Rotterdam 3015GD
NL
Dr. Molenwaterplein 40
Rotterdam 3015GD
NL
Listed location countries
Age
Inclusion criteria
The subject meets the new IASP clinical diagnostic criteria for CRPS {Harden, 2010} (<=diagnosis CRPS).
Age * 18 years.
Only one limb is affected.
Exclusion criteria
History of an auto-inflammatory or autoimmune disease.
Current treatment with immunomodulating medication or treatment within the last 6 months.
Ill in the past two weeks or at the time of the visit.
Knowledge of or confirmed pregnancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL66320.078.18 |