The aim of the project is to study the effect of INC1 and INC2 test compounds on typical features of the chronic disease psoriasis. This information can establish the most effective compound with the right formulation and dose for further research (…
ID
Source
Brief title
Condition
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Effect on typical psoriasis skin features after treatment with INC1 and INC2
test compounds.
Secondary outcome
-
Background summary
Psoriasis is an autoimmune disease in which proinflammatory protein mediators,
released by skin cells and infiltrating cells, cause abnormal cell division and
cell differentiation. It may be possible to treat psoriasis using drugs aimed
at preventing the synthesis of such mediators.
Study objective
The aim of the project is to study the effect of INC1 and INC2 test compounds
on typical features of the chronic disease psoriasis. This information can
establish the most effective compound with the right formulation and dose for
further research (e.g. in vitro, in vivo, clinical).
Study design
Non-Lesional skin biopsies of 6 mm in diameter will be treated with INC1 and
INC2 test compounds in the transplant model of psoriasis. By measuring the
effect on typical psoriasis skin features, it is possible to establish the most
effective compound with the right formulation and dose for further clinical
research.
Study burden and risks
The health risks associated with taking skin biopsies are small. It is possible
to obtain a slight scar formation and/or discolouration at the site of the
biopsy punch.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
Patients with moderate to severe psoriasis
Exclusion criteria
Volunteers undergoing UV/light therapy or taking systemic drugs such as cyclosporin A or methotrexate
Volunteers using local topical corticosteroids
Volunteers developing Köbner phenomenon at wound sites
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL68220.098.18 |