A unique and cutting-edge 7T imaging study to unravel subregional perturbations in structure and functional connectivity of deep-lying subcortical systems relevant to MDD pathophysiology.
ID
Source
Brief title
Condition
- Mood disorders and disturbances NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- MRI data on structural/functional properties of deep-lying subcortical brain
regions
- Clinical phenotypes of depression
- (Epi)Genetic data on relevant neurotransmitter systems
Secondary outcome
na
Background summary
Despite notable advances in recent years, neuropathological mechanisms
underlying Major Depressive Disorder (MDD) are still poorly comprehended and
this has lagged treatment development significantly. Whereas key subcortical
regions and their major subnuclei are theorized in animal and theoretical
models of affective psychopathology, commonly available neuroimaging techniques
lack the resolution to accurately probe the structural, functional, and
connectional integrity of these territories. This tends to preclude a
fine-grained, modular understanding of key subcortical brain systems in MDD,
and greatly limit translational and clinical utility of findings on the topic.
It is anticipated though that the use of ultra-high resolution MRI protocols
(*7 Tesla (7T)) will tackle these challenges, and allow for mesoscopic level of
detail to formulate more plausible neurobiological models of MDD. Despite its
undeniable merits, however, studies employing ultra-high resolution imaging in
MDD are largely lacking, owing to the technical and financial resources needed
to acquire and operate high field MRI machines.
Study objective
A unique and cutting-edge 7T imaging study to unravel subregional perturbations
in structure and functional connectivity of deep-lying subcortical systems
relevant to MDD pathophysiology.
Study design
cross-sectional, observational study comparing cases with controles
Study burden and risks
No specific risks are associated to participating in this observational MRI
study. The MRI scan employs magnetic field strengths and no from of hazardous
radiation is involved. Risk and discomfort associated to the blood draw
(venipuncture) may possibly be some slight pain and potential haemorrhage.
There is also the possibility of unexpected findings that may not be directly
relevant to the study but nonetheless carry significance for the participant's
physical and/or mental health. In such cases, the general practitioner of the
participant is informed and urged to inform the patient about the finding and
take further action. No other significant risks or disadvantages are
anticipated.
Oldenaller 1
Amsterdam 1081 HJ
NL
Oldenaller 1
Amsterdam 1081 HJ
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria patient sample;a) Primary diagnosis of major depression according to DSM-V criteria ;Inclusion criteria healthy control sample;b) No lifetime diagnosis of/treatment for depression or other psychopathology
c) Normal/subclinical scores on dimensional measures of psychopathology
Exclusion criteria
a) Psychoses, mania, Tourette*s syndrome, obsessive-compulsive disorder
b) Major internal or neurologic disorder
c) Traumatic head injury
d) Current substance abuse or dependence requiring treatment
e) Evidence of acute suicidal risk requiring intervention
f) MRI contradictions such as metal implants en claustrophobia
g) Left-handedness
h) Pregnancy
i) Insufficient knowledge of Dutch language
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL66885.029.18 |