This study has multiple purposes:Primary objective:1: to investigate whether it is possible to identify the small mimic muscles independently of each other and to determine the exact position of the mimic muscles from origin to insertion on MRI…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
geen aandoening, maar lokalisatie en beoordeling van het verloop en de functie van de mimische spieren
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1: correct identification of the mimic muscles would be considered to be
possible if the average volume of mimic muscle measured on MRI images by three
different investigators at three different times differ less than twenty
percent.
Secondary outcome
2: correct standardization of the positions of the mimic muscles is considered
to be possible if the average XYZ-coordinates, representing the origo and
insertion of a mimic muscle, determined by three different investigators at
three different times differ less than twenty percent.
3: correct superimposition is considered to be possible if the MRI images
correspond with the images on the 3D photograph.
4: the movement of the face in centimetres when changing facial expressions. A
change is defined as a deviation in position based on a XYZ-coordinate system.
5: the time in minutes a facial expression can be hold unchanged. A change is
defined as a deviation in position on a XYZ-coordinate system of more than
twenty percent.
The computer program 3DMD Vultus can be used to analyse three-dimensional
images from MRI and 3D photographs. Identified anatomical landmarks will be
registered as coordinates in a XYZ-coordinate system. Changes in corresponding
coordinates can indicate a change in for example a position of a muscle or an
ability to create facial expressions. A change in the direction of the X-axis
corresponds with a movement in a horizontal direction, a change in the
direction of the Y-axis corresponds with a movement in a vertical direction and
a change in the direction of the Z-axis corresponds with a movement in
ventro-dorsal direction. The computer program can also be used to analyse
differences between images by superimposition.
Background summary
It is known that facial traumas can lead to changes in facial expressions. A
disturbance in the normal anatomy might be the cause of this problem. A change
in the location of the origo or insertion of a muscle can result in a change in
the course of that muscle. As a result of this, the vector by which a muscle
exerts its force will change, thereby also changing its function in facial
expressions.
Also in case of elective surgery, some patients report the above-mentioned
change in facial expressions even after complete healing. This change is most
of the time unexpected and unpredicted and thereby unwanted by the patient as
well as by the surgeon. This seems in particular to be the truth after a Le
Fort 1 Osteotomy. Although these patients are convinced that their faces look
more attractive after having the surgery done, they don*t appreciate the change
in facial expressions. Especially a reduced ability to smile broadly, a very
important way of non-verbal communication, seems to be the cause for
disappointment. In severe cases it may even be that patients no longer
recognize their own faces as a result of the changed facial expressions.
Placing back the mimic muscles to the correct anatomical site seems to be
important in order to prevent the occurrence of any undesirable changes in
facial expressions after elective surgery and to pursue optimal restoration of
natural muscle function in reconstructive surgery after trauma. Detailed
knowledge about the exact position and the course of the mimic muscles from
origin to insertion is therefore considered essential.
A lot of research has been done recently regarding the (change in) position (of
parts) the facial skeleton after trauma and surgery by using three-dimensional
imaging techniques and CT-scans. However, still very little is known about the
mimic muscles of the face and their exact position and function.
The purpose of this research project is to learn all the details about the
mimic muscles. The aim is to find out whether it is possible to identify all
the small mimic muscles independently of each other (instead of identifying
mimic muscles as a group) and to determine their exact anatomical position from
origo to insertion to reveal their function based on their anatomical position
by using MRI and three-dimensional imaging.
With the results of this research project reference values could be made
regarding muscles positions and average excursions in facial expressions. These
reference values could be helpful to place back the muscles to their original
anatomic site during surgery in order to preserve or restore the facial
expressions of the patient in the best possible way and to quantify the changes
in facial expressions after trauma or surgery.
Study objective
This study has multiple purposes:
Primary objective:
1: to investigate whether it is possible to identify the small mimic muscles
independently of each other and to determine the exact position of the mimic
muscles from origin to insertion on MRI images, thereby defining the course of
these muscles and revealing their functions in facial expression.
Secondary objectives:
2: to investigate whether it is possible to standardize the positions of the
mimic muscles of the face using on MRI images and a XYZ-coordinate system.
3: to investigate whether it is possible to superimpose MRI images and 3D
photographs using the computer program 3DMD Vultus, thereby trying to connect
the course of a muscle with the facial expression to reveal the function of a
muscle.
4: to determine the average excursions in facial expressions.
5: to determine the duration a volunteer can hold a certain facial expression
unchanged.
Study design
Feasibility study
Study burden and risks
There are no risks for healthy volunteers associated with participation in this
study. The extend of the burden is minimal, there will only be a time
investment of approximately 30 minutes.
Heidelberglaan 100
Utrecht 3584 CX
NL
Heidelberglaan 100
Utrecht 3584 CX
NL
Listed location countries
Age
Inclusion criteria
age between 18 and 40 years
Exclusion criteria
surgery or trauma to the face or orthodontic treatment in the past
claustrophobia
physically or mentally incapable for MRI
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL57925.041.16 |