To compare the immunobiology of healthy volunteers to (advanced) cancer patients to age-matched controls with no history of cancer and no potentially interfering medication.
ID
Source
Brief title
Condition
- Immune disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary objective: mapping immune effector and suppressor functions in healthy
individuals, to be used as a tool in immuno-oncology research
Secondary outcome
Secondary objectives:
- Assessing and comparing the functionality of viral-epitope specific CD8+ T
cells in healthy volunteers with the functionality of viral-epitope specific
CD8+ T cells in cancer patients to gain insights into the possibility of a
systemically *exhausted* CD8+ T cell state in these patients
- Immunophenotyping of both myeloid and lymphoid cells in healthy controls to
gain insights in immunological defects and immune evasion in cancer patients
Background summary
We hypothesize that the immune system of cancer patients becomes more
dysfunctional as the disease progresses and that there is less
immunosuppression and/or immune evasion in healthy volunteers and early stage
cancer patients, as compared to patients with advanced disease.
Study objective
To compare the immunobiology of healthy volunteers to (advanced) cancer
patients to age-matched controls with no history of cancer and no potentially
interfering medication.
Study design
Healthy volunteers will be asked to donate 5 tubes of blood
Study burden and risks
Bruising at the side of the blood sampling
Plesmanlaan 121
Amsterdam 1066 CX
NL
Plesmanlaan 121
Amsterdam 1066 CX
NL
Listed location countries
Age
Inclusion criteria
- Age above 35 years
- Written informed consent
Exclusion criteria
- History of cancer
- Uuse of systemic immunosuppressive medication (eg. corticosteroids). Local use of corticosteroids (eg. topical or inhalation) is allowed.
- Fever 14 days before blood withdrawal
- Donated blood for the same program within the last 2 years
- Pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL66828.031.18 |