Determine the diagnostic accuracy of the AX area of the impulse oscillometry for asthma.
ID
Source
Brief title
Condition
- Respiratory disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The change of the AX area of the impulse oscillometry after taking Ventolin in
comparison with the diagnosis of the pulmonary phycicians. The change of the AX
area will be used to create an ROC-curve and the best cut off value will be
determined. For this cut off value the sensitivity, specificity, positive
prediction value, negative prediction value, positive likelihood ratio,
negative likelihood ratio and diagnostic odds ratio will be determined,
including their 95% confidence intervalls.
Secondary outcome
The change of the R5 and X5 of the impulse oscillometry after Ventolin in
comparison with the diagnosis of the pulmonary phycicians. The change of the R5
and X5 area will be used to create an ROC-curve and the best cut off value will
be determined. For this cut off value the sensitivity, specificity, positive
prediction value, negative prediction value, positive likelihood ratio,
negative likelihood ratio and diagnostic odds ratio will be determined,
including their 95% confidence intervalls.
The change of the FEV1 of spirometry after Ventolin in comparison with the
diagnosis of the pulmonary phycicians. The Mcnemar test will be used to see if
there is a significant difference between the diagnostic accuracy of the FEV1
of spirometry in comparison with the AX area of the impulse oscillometry.
The correlation between the R5, R20 and AX with the FEV1 will be determined.
Background summary
The impulse oscillometry is a simple pulmonary function test wich isn't widely
used in clinical practice. The measurement is not dependent on the effort of
the patient and causes a minimal amount of stress. Current literature shows
that the impulse oscillometry can be used in reversibility tests and inhalation
provocation tests.
Study objective
Determine the diagnostic accuracy of the AX area of the impulse oscillometry
for asthma.
Study design
The study is a diagnostic accuracy study (cross sectional) between the dianosis
of the pulmonary phycicians and the impulse oscillometry.
Study burden and risks
The extra measurement costs very little time and is not taxing for patients, no
additional risk is involved.
Lijnbaan 32
den Haag 2512VA
NL
Lijnbaan 32
den Haag 2512VA
NL
Listed location countries
Age
Inclusion criteria
Adult patients (18 years and older) who are redirected to a secondary health care institute with the presumed diagnosis of asthma who have given informed consent to be included in the study.
Exclusion criteria
Minors below 18 years of age, incapacitated adults and subject who have not signed the informed consent form.
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL61597.098.17 |