To investigate the timing and coordination of speech articulation of PD patients. This information will lead to a better understanding of dysarthria and will ultimately aid speech therapy.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study endpoints parameters are:
- Displacement of the tongue tip, the tongue body, the lips and the jaw at
consonant and vowel targets.
- Velocity of tongue of the tongue tip, the tongue body, the lips and the jaw
at key landmarks of speech gestures.
- Duration of speech gestures produced with of the tongue tip, the tongue body,
the lips and the jaw.
- Speech rate (syllables/min and words/min).
Secondary outcome
The secundary study endpoints parameters are:
- F1 and F2 formant measures during the production of vowels (acoustic)
- Intensity of the speech signal during the production of stops (acoustic)
Background summary
Due to a loss of dopaminergic cells in the substantia nigra, persons who are
diagnosed with Parkinson*s Disease (PD) have movement difficulties. As speech
requires subtle motor movements and muscle coordination, it is commonly found
to be affected in PD. This speech disorder, known as hypokinetic dysarthria,
can lead to severe communication problems that affect the quality of life of
patients. Symptoms of hypokinetic dysarthria are, amongst others, monopitch,
reduced variation of pitch, monoloudness, unclear articulation and untypical
coordination. In this study, we will specifically investigate consequences at
the articulatory level of speech (e.g., imprecise production of consonants). We
hypothesize that PD patients show deviant speech kinematics in comparison to a
group of non-speech disturbed controls. More specifically, based on previous
acoustic studies, we hypothesize that the displacement of the articulators will
be reduced for the PD group and that the coordination of articulatory movements
will deviate from the coordination as observed in non-speech disturbed
controls.
Study objective
To investigate the timing and coordination of speech articulation of PD
patients. This information will lead to a better understanding of dysarthria
and will ultimately aid speech therapy.
Study design
Subjects will answer to questions from the SCOPA-COG and perform several speech
tasks. During these tasks, articulatory trajectories will be recorded using
both electromagnetic articulography (EMA) and ultrasound tongue imaging (UTI).
The data from the PD patients will be
compared to the data from non-speech disturbed controls.
Study burden and risks
No known risks or benefits are associated with participation in this study.
Oude Kijk in 't Jatstraat 26
Groningen 9712 EK
NL
Oude Kijk in 't Jatstraat 26
Groningen 9712 EK
NL
Listed location countries
Age
Inclusion criteria
- At least 18 years of age
- Mother tongue speaker of Dutch;Only for the PD group:
- Diagnosed with idiopathic Parkinson*s disease (according to the UK Parkinson*s Disease Society Brain Bank Clinical Diagnostic Criteria)
Exclusion criteria
- Older than 80 years of age
- A score of 2 or higher on part 1.1 (cognitive impairment) or part 1.2 (hallucinations and psychosis) of the UPDRS
- History of neurological or psychological disorders
- Self-reported signs of depression
- Self-reported swallowing problems
- Stuttering or other speech and language problems
- Non removable metal on, in or close to the head (e.g., piercings, dental braces, medical devices such as deep brain stimulation electrodes)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL66063.042.18 |