The aim of the project is to study the effect of CDor and CDiv test compounds on typical skin features of psoriasis. This information can establish the most effective compound, right formulation and dose for further clinical research.
ID
Source
Brief title
Condition
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Effect on epidermal ridge thickness after treatment with CDor and CDiv test
compounds.
Secondary outcome
-
Background summary
Psoriasis is an autoimmune disease in which proinflammatory protein mediators,
released by skin cells and infiltrating cells, cause an abnormal cell division
and differentiation. It may be possible to treat psoriasis using drugs aimed at
preventing the synthesis of such mediators.
Study objective
The aim of the project is to study the effect of CDor and CDiv test compounds
on typical skin features of psoriasis. This information can establish the most
effective compound, right formulation and dose for further clinical research.
Study design
Non-lesional skin biopsies of 6 mm in diameter will be treated with CDor and
CDiv test compounds using the transplant model of psoriasis. By measuring the
effect on epidermal ridge thickness of the skin, it is possible to establish
the most effective compound, the right formulation and dose for further
clinical research.
Study burden and risks
The health risks associated with taking blood & skin biopsies are small. It is
possible to obtain a slight scar formation and/or discolouration at the site of
the biopsy punch.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
Patients with moderate to severe psoriasis
Exclusion criteria
Volunteers undergoing UV/light therapy or taking systemic drugs such as cyclosporin A or methotrexate
Volunteers using local topical corticosteroids
Volunteers developing Köbner phenomenon at wound sites
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL68317.098.18 |