Assess the correlation between multiple neurophysiological measurements and complex motor learning in healthy subjects.
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Motor Learning: The accuracy on a sequential visual isometric force pinch task
(SVIPT), will be used to measure motor skill. Motor learning is defined as the
difference between the first day and the last day. //
Local excitation: Local excitation will be measured with a single pulse motor
map procedure. A motor map is the area on the skull from which a TMS pulse can
stimulate the target muscle. The volume is the sum of the MEP aplitudes in this
area//
Local inhibition: Local inhibition is mediated by GABAa-ergic and GABAb-ergic
interneurons. GABAa-ergic local inhibition will be measured with a paired pulse
procedure called short interval intracortical inhibition (SICI). The first
pulse is a subthreshold pulse that depolarizes the GABAa-ergic interneurons,
which reduces the MEP amplitude of the second suprathreshold pulse. The outcome
measure is the amplitude ratio between paired pulses and single pulses.
GABAb-ergic local inhibition will be measured with a single pulse procedure
called the cortical silent period (cSP). The subject is contracting the target
muscle while the magnetic pulse is applied. This produces a short depression of
the EMG signal. The outcome measure is the duration of this silent period.//
Transcallosal inhibition: Transcallosal inhibition will be measured with a
single pulse protocol called the ipsilateral silent period (iSP). The subject
is contracting the homologous muscle, ipsilateral of the stimulated motor
cortex. The magnetic pulse excites a GABAb mediated transcallosal network that
inhibits the contralateral motor cortex, which produces a short depression in
the EMG signal of the ipsilateral muscle. The outcome measure is the duration
of this silent period.//
Secondary outcome
Assess how the neurophysiological measurements change and interact during
multiple sessions of motor training.
Background summary
Stroke is a leading cause of long-term adult disability. The ability of stroke
patients to independently undertake activities of daily living is highly
dependent on motor function of the upper limbs. Current prognostic algorithms
for the upper limb use the ability to make basic movements 3 days post stroke
as a predictor for functional recovery. However, approximately 30% of stroke
patients show substantially less improvement than predicted by early
post-stroke ability. Functional recovery after stroke is mediated by both
natural repair and motor learning. It has been proposed that lagging stroke
patients have a deficit in brain plasticity which impairs motor learning and
thus prevents them from reaching their full potential for functional recovery.
If these patients are detected at an early stage they could benefit from novel
noninvasive brain stimulation therapies in the rehabilitation clinic.
The goal of this experiment is to assess the correlation between complex motor
learning and multiple brain plasticity measurements in healthy subjects. Local
excitation, local inhibition and transcallosal inhibition will be assessed. In
this study these measurements will be conducted with Transcranial Magnetic
Stimulation (TMS). With this technique, magnetic pulses are applied to the
brain with a small coil placed over the head. When the coil of the TMS
apparatus is held over the primary motor cortex, a pulse can excite or inhibit
motorneurons that target a specific muscle, depending on the background
contraction. These Motor Evoked Potentials (MEPs) or silent periods are
measured with an electromyography (EMG) apparatus. In this study, multiple TMS
measurements will be conducted in healthy subjects before and after multiple
motor training sessions.
Study objective
Assess the correlation between multiple neurophysiological measurements and
complex motor learning in healthy subjects.
Study design
Prospective cohort study
Study burden and risks
Participants will visit the Erasmus MC on 3 days for a total of 11 hours. In
this study safety measures are applied according to Rossi et al (2012).
Therefore, there is no elevated risk of seizures or other serious events. This
study will not use repetitive TMS. Only single pulse and paired pulse protocols
will be used. The risks associated with this study are small. The discharging
of the coil at higher intensity levels can produce loud sounds. Therefore, both
subjects and the experimenter will wear ear plugs. Furthermore, discharging the
coil could cause temporary discomfort on the head.
There is no direct therapeutic benefit, because there are no interventions and
the subjects are healthy volunteers. Subjects will receive a financial
compensation for expenses made due to participation.
Wytemaweg 90
Rotterdam 3015CN
NL
Wytemaweg 90
Rotterdam 3015CN
NL
Listed location countries
Age
Inclusion criteria
Healthy//
Aged 18-35//
Right handed
Exclusion criteria
History of neurological or psychiatric disorders
Implants or metal parts in the head
Use of psychoactive drugs in the last month
Neuromodulatory stimulation in the last month
Pregnant
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL58087.078.16 |