To explore the multimodal correlates of cognitive functioning through the framework of *multilayer connectomes*, in which EEG/MEG/rsfMRI/dMRI will each be represented as layers of the brain network, and MRS will be used to further investigate the…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
normaal cognitief functioneren
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
cognitive functioning in the domains of (1) executive functioning, (2) working
memory, (3) information processing speed, (4) verbal memory, (5) psychomotor
speed, (6) attention, and (7) spatial memory.
Secondary outcome
not applicable.
Background summary
Improving our knowledge on the cognitive correlates of connectomes, the
anatomical/functional connectivity patterns and their topology in the brain,
has been a key aim in recent neuroscience. Indeed, cognitive test performance
is strongly related to anatomical and functional connectivity patterns in the
brain. These patterns can be measured with several types of macroscopic
imaging, such as electroencephalography (EEG)/magnetoencephalography (MEG),
resting-state functional magnetic resonance imaging (rsfMRI), and diffusion
magnetic resonance imaging (dMRI), while magnetic resonance spectroscopy (MRS)
may give additional information on the metabolism underlying connectivity. Once
connectivity is measured, network theory can be used to explore which
properties of the brain network most strongly associate with cognition, as has
been amply shown within the abovementioned imaging modalities. However, the
link between cognition and multimodal imaging characteristics remains largely
unknown, even though recent studies suggest that multimodal predictors
supersede unimodal correlates of cognitive functioning.
Study objective
To explore the multimodal correlates of cognitive functioning through the
framework of *multilayer connectomes*, in which EEG/MEG/rsfMRI/dMRI will each
be represented as layers of the brain network, and MRS will be used to further
investigate the biological metabolic mechanism occurring in a particular region
of the brain network.
Study design
Observational study.
Study burden and risks
The burden associated with participation consists of a number of visits to the
outpatients* clinic for neuropsychological testing, MEG/EEG measurements and
MRI scanning. No health-related risks are involved in this study. In our view,
the burden associated with participation is proportionate to the potential
value of the research for all clinical populations studied within Amsterdam
Neuroscience.
De Boelelaan 1108
Amsterdam 1081 HZ
NL
De Boelelaan 1108
Amsterdam 1081 HZ
NL
Listed location countries
Age
Inclusion criteria
-age between 20 to 70 years old
-native Dutch speaker
-able to provide written informed consent
Exclusion criteria
-history of any neurological or psychiatric disease, including traumatic head injury
-current and regular use of centrally acting drugs (recreational or prescribed, including analgesics), including the use of alcohol or caffeine on the visit days
-presence of any contraindications for MRI, MEG, or EEG.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL66000.029.18 |
| OMON | NL-OMON24919 |