Main objectives:- Investigating the relation between language functioning and resting-state EEG characteristics in brain tumour patients.- Predicting language outcome after brain tumour surgery, on the basis of pre-operative EEG characteristics.…
ID
Source
Brief title
Condition
- Nervous system neoplasms benign
- Nervous system, skull and spine therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Language abilities of low-grade glioma and meningioma patients before
surgery, shortly after surgery, and at the long-term follow-up.
- The relation between language functioning and resting-state EEG
characteristics in brain tumour patients.
- Pre-operative EEG characteristics that predict language outcome after brain
tumour surgery.
Secondary outcome
- Network characteristics that are associated with specific linguistic deficits.
- Associations between language and performance in other cognitive domains.
- The relation between the severity of the language disorder and the quality of
life in brain tumour patients before and after surgery.
Background summary
Primary low-grade brain tumours can cause language deficits that affect the
quality of life. These language deficits do not always recover after brain
tumour surgery. Several factors can have an influence on the course of
recovery, such as tumour grade and/or the extent of an intact neural network.
Previous studies related slow-wave brain activity and neural network
characteristics to cognitive functioning in brain tumour patients (e.g. Bosma
et al., 2008, 2009), but the relation between brain activity and functional
networks on one hand and language functioning on the other has not been
investigated yet. The current study aims to find predictors for language
outcome after surgery of a low-grade glioma or meningioma, by using
resting-state electroencephalography (EEG).
Study objective
Main objectives:
- Investigating the relation between language functioning and resting-state EEG
characteristics in brain tumour patients.
- Predicting language outcome after brain tumour surgery, on the basis of
pre-operative EEG characteristics.
Secundary objectives:
- Examining network characteristics that are associated with specific
linguistic deficits.
- Studying how language is related to other cognitive functions in brain tumour
patients.
- Revealing how the severity of the language disorder is related to the quality
of life in brain tumour patients before and after surgery.
Study design
This is a longitudinal observational study consisting of two patient groups and
a control group without brain injury. The patient groups will get an EEG
recording, language assessment, a few neuropsychological tests, and
questionnaires before surgery. The language assessment, neuropsychological
tests, and questionnaires will be repeated twice after surgery: 1,5-3 months
and 1 year post-operatively. A EEG will be performed twice in patientgroup 1
(preoperative and 1 year postoperative).The control group will be assessed with
an EEG recording, a spontaneous speech interview and a questionnaire.
Study burden and risks
EEG recording is performed only once, before surgery in patientgroup 2 and
twice in patientgroup 1 (preoperative and 1 year postoperative). This is a
standard procedure in most brain tumour patients, because of suspected
epileptic seizures, and is completely safe.
The language assessment, neuropsychological tests, and questionnaires will be
conducted thrice: before, 1.5-3 months after, and 1 year after surgery. No
risks are associated with the assessments, apart from fatigue. If patients
wish, they will get feedback about their performance and advice on
post-operative language rehabilitation.
Oude Kijk in't Jatstraat 26
Groningen 9712EK
NL
Oude Kijk in't Jatstraat 26
Groningen 9712EK
NL
Listed location countries
Age
Inclusion criteria
Patient group 1:
- Diagnosis of a radiologically presumed low-grade glioma; according to the judgement of radiologist, neurosurgeon or neurologist.
- Location in the language dominant hemisphere (if unknown: right-handed and left-sided tumour)
- Tumour is untreated
- Planned to undergo awake brain surgery
- In case of epilepsy, seizures under control with anti-epileptic drugs (less than six seizures in the previous year and on anti-epileptic monotherapy or polytherapy)
- Between 18 and 75 years old;Patient group 2:
- Diagnosis of an intracranial, supratentorial meningioma
- Location in the left hemisphere
- Location: falcine and parasaggital meningiomas, when located at the skull base only sphenoid wing, and tentorial meningiomas when located supratentorially
- Diameter > 3 cm
- Tumour is untreated
- Planned to undergo brain surgery
- Presumed low-grade
- Language dominance in the left or right hemisphere
- In case of epilepsy, seizures under control with anti-epileptic drugs (less than six seizures in the previous year and on anti-epileptic monotherapy or polytherapy)
- Between 18 and 75 years old;Control group (comparable to the patient groups with respect to age, gender and education):
- right-handed
- between 18 and 75 years old
Exclusion criteria
For the patient groups:
- Non-native speaker of Dutch or insufficient command of the Dutch language
- History of a medical, neurological or psychiatric condition known to affect language or cognitive functioning
- (History of) substance abuse
- Use of medication known to influence language or cognitive functioning, other than anti-epileptic drugs
- Use of dexamethasone pre-operatively (peri-operatively according to local protocol is not an exclusion criterion)
- Use of medication known to influence EEG, other than anti-epileptic drugs
- Previous brain surgery or cranial radiation therapy;For the control group:
- Non-native speaker of Dutch or insufficient command of the Dutch language
- History of medical, neurological or psychiatric condition known to affect language or cognitive functioning
- (History of) substance abuse
- Use of medication known to influence language or cognitive functioning
- Use of medication known to influence EEG
- Previous brain surgery or cranial radiation therapy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL56362.042.16 |
| Other | NTR-nummer: NTR5811 |
| OMON | NL-OMON28627 |