This study aims to determine the digestibility of AAs in two protein sources in men and women with normally functioning ileostomies.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
alle, eiwit kwaliteit is van belang voor de juiste keuze voor een eiwitbron in de voeding.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Ileal AA digestibility of Zein and Whey Protein Isolate.
Secondary outcome
n/a
Background summary
The evaluation of protein quality has top priority according to Food and
Agricultural Organization (FAO) of the United Nations. However, one aspect of
protein quality, namely the digestibility of protein is largely unknown. A
database on this matter is lacking as it is difficult to measure ileal
digestibility in humans.
Study objective
This study aims to determine the digestibility of AAs in two protein sources in
men and women with normally functioning ileostomies.
Study design
Intervention study with 6 test days, testing 3 meals each twice.
Intervention
On six separate test days, subjects will receive a meal, consisting of a drink
and biscuit. With this, two different protein containing meals, i.e. zein and
whey, and a protein-free meal is tested; these three treatments are given at
two occasions, thus in total 6 meals are tested. After consumption of the meal,
subjects collect their digesta for nine hours.
Study burden and risks
The subject will not benefit from the study except for the contribution to
scientific research. Risk associated with intake compounds of the meal is
negligible. Subjects have to come to the research facility seven times, a
screening visit of 1 hour, and 6 experimental days of 10 hours. Subjects will
be financially compensated for participation.
Stippeneng 4
Wageningen 6708 WE
NL
Stippeneng 4
Wageningen 6708 WE
NL
Listed location countries
Age
Inclusion criteria
* Male or female
* Age between 18 and 60
* BMI between 18,5 and 27 kg/m2
* Willing to eat animal protein
* Have a well-established and normally functioning terminal ileostomy, with stomal faeces of normal physiological consistency
* Good general health, meaning subjects should be well-recovered from the ileostomy operation, their underlying disease should be cured or in remission and they should not have any other major health problems.
Exclusion criteria
* Taken antibiotics or medication that majorly impair small intestinal digestion and absorption within eight weeks of participating in the study.
* Have been pregnant or breastfeeding in the last 12 months, or plan to become pregnant during the study
* Having renal impairment, coeliac disease or diabetes
* Drug abuse
* Alcohol consumption of >14 units per week
* Having an allergy or intolerance to dairy, corn products or fructose
* Currently taking protein supplements and would not be willing to stop using these during the study
* Being on a controlled diet or dietary weight loss regimen during the two weeks prior to the start of this study and/or during the study
* Personnel of division of Human Nutrition, Wageningen University..
* Current participation in other research from the Division of Human Nutrition
* Not having a general practitioner
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL63446.081.17 |