Establishment of a quantitative relationship between NIR measurements and body fluid balance in research subjects exposed to accelerated dehydration by cycling exercise on a home trainer. This explorative study will generate detailed information of…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
lichaamshydratatie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Establishment of a (quantitative) relationship between diffuse reflectance NIR
spectroscopy measurements on the skin (both positively and negatively
correlated wavelengths) with the body fluid balance using a limited set of
research subjects. Body weight will be used as reference for the body fluid
balance. BIA will be used as a second line control. This pilot study will
generate detailed information needed to verify the suitability of protocols and
methods in order to develop the final protocol for a subsequent main study.
Secondary outcome
Not applicable.
Background summary
Assessment of the body fluid balance in humans by non-invasive and continuous
optical measurements, like near-infrared spectroscopy (NIR) can significantly
contribute to the prevention of dehydration in elderly but also in athletes
during prolonged endurance exercise. Serious dehydration in elderly may result
in cardiac and mental health problems ending up in hospitalization.
Personalized early warning of dehydration will contribute to a better life for
elderly and a decrease of hospitalization.
For athletes, dehydration of as little as 2% of the body weight can impair
aerobic exercise performance. The proper assessment of an athlete*s hydration
status before, during, and after exercise is warranted. Equilibration of water
saturation will enhance the sports performance.
Study objective
Establishment of a quantitative relationship between NIR measurements and body
fluid balance in research subjects exposed to accelerated dehydration by
cycling exercise on a home trainer. This explorative study will generate
detailed information of the minimum amount of dehydration which is required to
establish a clear difference in NIR signals between the hydrated and the
dehydrated state of the athletes.
Study design
Ten research subjects are recruited to participate in this experimental study.
Parallel measurements of body weight (hydration status) and NIR of the skin
surface are conducted during 90 min. of moderate-intensity cycling exercise and
after 60 min of recovery. During the recovery period, research subjects ingest
an isotonic sport drink providing 100% of the body weight loss. The
relationship between body weight and NIR data will be assessed. As second
reference method, bioelectric impedance measurements will be performed at the
start, mid-point (90 min.) and end of the study (150 min.) The experimental
protocol will be repeated three times.
Intervention
Intervention consists of performing physical exercise.
Study burden and risks
Research subjects will have to cycle 3 times on a cycle ergometer over a period
of 6 weeks with a minimum of one week between replicates. There are no
additional risks associated with the measurements in this experimental study.
The research subjects will have to perform a 90 min bout of cycling exercise at
60-70% of the estimated maximal heart rate (70% HRmax, estimated by equation
HRmax = 220 * age). This will results in fatigue, and can give rise to some
muscle soreness (in the days) after exercise. However, only physically active
and healthy research subjects are selected. Total duration of the experiment
will be approximately 3 hours.
Stippeneng 4
Wageningen 6708 WE
NL
Stippeneng 4
Wageningen 6708 WE
NL
Listed location countries
Age
Inclusion criteria
Healthy and physically active male subjects (self-reported sport participation minimum 2 times per week during the last 6 months), age from 18 to 30 years. Research subjects have to know from their selves that they sweat extensively upon exercise (self-reported by self-estimation). For homogeneity of the study population, only Caucasian males will be included. Moreover differences in skin colours may influence the NIR signal of the skin.
Exclusion criteria
Research subjects who use any medication or (psycho)pharmaceuticals. Research subjects who suffer from chronic or metabolic diseases. Research subject who use pace-makers.
Design
Recruitment
Medical products/devices used
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In other registers
| Register | ID |
|---|---|
| CCMO | NL64913.081.18 |