1. To study the differential effectiveness of three cueing modalities on gait parameters, gait stability, and interlimb coordination in people with Parkinson's disease 2. To study the differences between self-selected and a 10% increased cueing…
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameter for gait pattern: Stride length, stride frequency and
walking speed.
Secondary outcome
Parameters for differences in gait stability: Center of mass velocity, center
of mass medio-lateral deviation, interstep time variability.
Next to these secondary outcome parameters, interlimb coordination will be
assessed.
Descriptive study parameters:
- Clinical characteristics: Unified Parkinson*s Disease Rating Scale,
- Walking performance: 10 meter walk test; freezing of Gait Questionnaire
- Balance performance: Single leg stance test
- Duration of the disease
Background summary
Patients with Parkinson*s disease (PD) commonly experience problems with
mobility (ie. gait and gait related activities). The gait pattern is
characterized by reductions in walking speed and stride length and increased
cadence. Another core feature of PD is postural instability, which can result
in falls and subsequent injury. Another feature that has not been well
investigated is interlimb coordination. Interlimb coordination, both
ipsilateral and contralateral, is known to be reduced in people with PD and is
found to be negatively associated with clinical scores of gait and posture. The
inclusion of external rhythmic cueing as a prolonged adjuvant to rehabilitation
therapy has been demonstrated to improve gait impairments substantially in most
patients. In this study, 3 modalities will be used, somatosensory, visual and
auditory.
Though all three sensory cueing modalities have shown to be effective to some
extent, differences in effectiveness between these types have not been
systematically investigated in overground walking. The aim of this study is
therefore to extend the literature by investigating the differences in
effectiveness between the modalities during overground walking.
We hypothesize that vibrotactile cueing is a viable alternative to auditory
cueing. In addition, we hypothesize that the effectiveness of both auditory and
vibrotactile cueing will be superior to visual cueing in terms of gait pattern,
stability and interlimb coordination.
Study objective
1. To study the differential effectiveness of three cueing modalities on gait
parameters, gait stability, and interlimb coordination in people with
Parkinson's disease
2. To study the differences between self-selected and a 10% increased cueing
frequency on gait parameters, gait stability, and interlimb coordination in
people with Parkinson's disease?
Study design
This study will be a group study with a cross-sectional design comparing three
cueing conditions within subjects. There will be no control/healthy group
included, since it has been well established that external rhythmic cueing
helps people with PD to walk with a higher speed, frequency, and greater stride
length.
Intervention
Patients walk with external rhythmic cues
Study burden and risks
There are no risks associated with the tasks participants have to perform. Time
burden is ~1.5 hrs for the actual experiment (including
preparation and debriefing). There is no known direct benefit without
conducting an analysis.
Boelelaan 1117
Amsterdam 1007 MB
NL
Boelelaan 1117
Amsterdam 1007 MB
NL
Listed location countries
Age
Inclusion criteria
Ambulatory patients showing mild to severe gait disturbance with score >1 on the Unified Parkinson*s Disease Rating scale (UPDRS; motor section)
Idiopathic Parkinson*s disease
stable drug usage
Moderate disease severity (Hoehn and Yahr stage II-III)
age 40-80
Exclusion criteria
significant hearing/vision loss, or significant somatosensory impairment. (Such that it may intervene with our methods)
if a participant had undergone deep brain stimulation (by means of an interview)
has unpredictable and long lasting off periods (by means of an interview)
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL65021.029.18 |