To investigate whether atopic dermatitis patients can be stratified based on integral analysis of clinical patient data complemented by novel biophysical measurements, in-vivo Raman spectroscopy, microbiome swabs and a oral mucosa swab (one time).
ID
Source
Brief title
Condition
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Correlation between clinical patient data and LPR (Measured with Raman
Spectroscopy)
Secondary outcome
Correlation between clinical patient data and Natural Moisterizing Factor
(NMF), measured with Raman Spectropscopy
Correlation between clinical patient data and alterations in skin microbiome
Correlation between clinical patient data and alterations in nose microbiome
Integral correlation between clinical patient data and all biophysical
measurements
Background summary
Stratification of atopic dermatitis patients is relevant to improve health care
for these patients. This is a prospective study. For this study, in vivo Raman
spectroscopy measurements on the skin of patients will be performed to
determine the lipid-to-protein ratio (LPR) in the skin, microbiome swabs will
be taken of the skin and mucosa of the nose and oral mucosa swabs will be taken
for fillagrin DNA analysis. It is expected that the biophysical measurements
can be associated with clinical aspects of the disease, under which disease
severity, and can therefore provide new possibilities for stratification of
patients.
Study objective
To investigate whether atopic dermatitis patients can be stratified based on
integral analysis of clinical patient data complemented by novel biophysical
measurements, in-vivo Raman spectroscopy, microbiome swabs and a oral mucosa
swab (one time).
Study design
prospective observational study.
Study burden and risks
The biophysical measurements done during this study are non-invasive, painless
and not harmful. Skin and nose swabs for microbiome analysis and the oral
mucosa swab take around three minutes. In vivo Raman spectroscopy measurements
for determination of LPR take in total approximately 15 minutes, during which
the patient has to sit still during each repeat measurement of about one minute.
The risks associated with participation are negligible. Because atopic
dermatitis is a disease mainly affecting children it is important to
investigate possible parameters in especially this group of patients.
Burgemeester s' Jacobplein 51
Rotterdam 3015 CA
NL
Burgemeester s' Jacobplein 51
Rotterdam 3015 CA
NL
Listed location countries
Age
Inclusion criteria
Aged between 0-18 years
Indication of atopic dermatitis
Exclusion criteria
No informed consent.
Patients and their parents or guardian do not speak Dutch.
Patients and their parents or guardian have no access to internet or are not able to use the online questionnaires.
Applying ointments or oil on the skin of the arm and hand on the day of visit to the dermatologist
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL62118.078.17 |