To investigate the effect of subjective beliefs on motivated behavioral responses following frontal transcranial direct current stimulation (tDCS) in healthy volunteers.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
onderzoek bij gezonde vrijwilligers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Average reaction times in milliseconds.
Secondary outcome
not applicable
Background summary
Transcranial direct current stimulation (tDCS) is routinely applied to
investigate psychological functioning. A priori beliefs about the effects on
the efficacy of tDCS may interact with the actual observed behavioral effects.
However the moderating effect of subjective beliefs has not been systematically
studied in tDCS studies.
Study objective
To investigate the effect of subjective beliefs on motivated behavioral
responses following frontal transcranial direct current stimulation (tDCS) in
healthy volunteers.
Study design
Sham-controlled partly double blind mixed subjects design.
Intervention
Participants will be randomly assigned into one of two groups, One group will
receive information that tDCS is highly effective, while the other group will
receive information that tDCS does not work.
Transcranial direct current stimulation (tDCS) will be delivered by a
battery-driven electric current stimulator (Eldith DC Stimulator (CE 0118),
llmenau) using a pair of 3x5 cm electrodes placed over the left (ANODE) and
right dorsolateral prefrontal cortex (CATHODE). Stimulation at an intensitiy of
2 mA will be delivered for 25-30 minutes during a cognitive motor task.
Study burden and risks
The currently proposed tDCS procedure and experiment does not carry any
significant risks. Stimulation will be performed in line with the Standard
Operating Procedure Non-Invasive Brain Stimulation of the Donders Institute for
Brain, Cognition and Behaviour. Potential side-effects of tDCS are itching or
burning sensations on the under the electrodes, light headache and/or fatigue.
These are mild discomforts that respond promptly to common analgesics.
Volunteers can withdraw from the study at any given time and there are no
direct benefits for the participants. The novel insights will broaden our
fundamental understanding on the psychological factors, here subjective
expectations about efficacy of DC stimulation, on the actual effect of real DC
stimulation.
Montessorilaan 3
Nijmegen 6525HR
NL
Montessorilaan 3
Nijmegen 6525HR
NL
Listed location countries
Age
Inclusion criteria
Between 18-35 years of age years; Right-handed; Non-smoking; Normal or corrected-to-normai vision;
Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements.
Exclusion criteria
1) Average use of more than 3 alcoholic beverages daily; (2) Use of psychotropic medication or recreational drugs; (3) Skin disease; (4) Pregnancy; (5) Serious head trauma or brain surgery; (6) Neurological or psychiatric disorders; (7) Large or ferromagnetic metal parts in the head (except for a dental wire); (8) Implanted cardiac pacemaker or neurostimulator; (9) Participation in a NBS study in the past 28 days.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL65301.091.18 |