To study the interaction between normal T lymphocytes and Hodgkin tumor cells in an in vitro model.
ID
Source
Brief title
Condition
- Lymphomas Hodgkin's disease
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Disentangling mechanisms of interaction between lymphocytes and Hodgkin tumor
cell lines in vitro.
Secondary outcome
geen
Background summary
Hodgkin lymphoma is a specific type of lymphoma in which T lymphocytes are
known to play an important role in its pathogenesis. These T lymphocytes are
directly surrounding the tumor cells. The reason for this interaction is
unclear and it is puzzling why the tumor cells are not killed. Instead of
killing, the T lymphocytes actually strongly support the survival and growth of
the tumor cells. We have developed an in vitro model in which normal T
lymphocytes from blood are allowed to react with Hodgkin lymphoma tumor cell
lines. With this model inititiation and mechanisms of interaction can be
studied. The Human Leukocyte Antigen is expected to be important.
Study objective
To study the interaction between normal T lymphocytes and Hodgkin tumor cells
in an in vitro model.
Study design
Human leukocyte antigen matched lymphocytes from healthy individuals will be
added to Hodgkin cell lines in vitro. Interaction between the cells will be
measured by timing and showing which molecules are involved.
Study burden and risks
Burden and risk of routine venapuncture are very low.
Hanzeplein 1
Groningen 9700RB
NL
Hanzeplein 1
Groningen 9700RB
NL
Listed location countries
Age
Inclusion criteria
Age > 18 years
Ability to give written informed consent
HLA type known
Exclusion criteria
active infectious, autoimmune or malignant disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL64963.042.18 |