An Open-label, Non-randomised, Multicentre Study to Allow Continued Access to and Assess the Safety and Tolerability of AZD1775 for Patients Enrolled in AZD1775 Clinical Pharmacology Studies

1. Has read and understands the informed consent form (ICF) and has given written
informed consent prior to any study procedures.
2. Female or male aged *18 years.
3. Has completed 1 of the parent AZD1775 clinical pharmacology studies (ie,
D6014C00002, D6014C00003, D6014C00004, D6014C00005, or D6014C00006)
and in the Investigator*s opinion will continue to benefit from treatment with
AZD1775. Patients who discontinue early from the parent study will be considered
by the Sponsor and treating physician on a case-by-case basis.
4. Any prior radiation must have been completed at least 7 days prior to the start of
study treatment, and patients must have recovered from any acute effects prior to
the start of study treatment.
5. Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 to 1.
6. Baseline laboratory values within 7 days of study treatment initiation in the CA
study:
* Absolute neutrophil count (ANC) *1500/*L.
* Haemoglobin *9 g/dL.
* Platelets *100,000/*L.
* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST)
*3 x upper limit of normal (ULN) or *5 x ULN if known hepatic
metastases.
* Serum bilirubin within normal limits or *1.5 x ULN in patients with liver
metastases; or total bilirubin *3.0 x ULN with direct bilirubin within
normal limits in patients with well documented Gilbert*s Syndrome.
* Serum creatinine *1.5 x ULN, or measured creatinine clearance (CrCl)
calculated by Cockcroft-Gault method *45 mL/min (confirmation of
creatinine clearance is only required when creatinine is >1.5 x ULN)
(CrCl (glomerular filtration rate) <= (140-age) x (weight/kg) x Fa) /
(72 x serum creatinine mg/dL) awhere F <= 0.85 for females and F <= 1 for males.
7. Female patients who are of non-childbearing potential and fertile women of
childbearing potential (WoCBP) who agree to use adequate contraceptive measures
that are in place during screening (or consent), for the duration of the study, and for
1 month after treatment stops; who are not breastfeeding; and who have a negative
serum or urine pregnancy test prior to the start of study treatment.
8. Male patients must be willing to use barrier contraception (ie, condoms) for the
duration of the study and for 3 months after study treatment discontinuation.
9. Willingness and ability to comply with the study and the follow-up procedures.

1. Involvement in the planning and/or conduct of the study (applies to both
AstraZeneca personnel and/or personnel at the study centre).
2. Previous enrolment and received study treatment in the present study. Patients can,
however, be re-screened if the reason for the screen failure no longer exists.
3. Concurrent enrolment in another clinical study, unless it is an observational
(non-interventional) clinical study or the follow-up period of an interventional
study.
4. Must not have received another systemic anti-cancer therapy in the interval
following participation in the AZD1775 clinical pharmacology study and the start
of treatment on the CA protocol.
5. Not developed any clinical findings suggestive of brain metastasis. Patients
continue to be neurological stable and remain off systemic corticosteroids following
treatment of known brain metastases.
6. Did not tolerate AZD1775 in the parent study in the opinion of the Investigator.
7. Where a course of palliative radiotherapy was indicated, the last fraction must have
been delivered before the start of study treatment on the CA study.
8. Major surgical procedures *28 days of beginning study treatment, or minor surgical
procedures *7 days. No waiting period required following port-a-cath placement or
other central venous access placement.
9. Grade >1 toxicities from prior therapy, according to the Common Terminology
Criteria for Adverse Events (CTCAE), excluding alopecia or anorexia.
10. Continue to be able to swallow oral medication, did not undergo placement of a
percutaneous endoscopic gastrostomy tube and did not require total parenteral
nutrition.
11. Has had prescription or non-prescription drugs or other products known to be
sensitive to CYP3A4 substrates or CYP3A4 substrates with a narrow therapeutic
index, or to be moderate to strong inhibitors/inducers of CYP3A4 between the
parent study and entry into this CA study. Co administration of aprepitant or
fosaprepitant during this study is prohibited.
12. Has consumed herbal preparations between the parent study and entry into this CA
study.
13. Has consumed grapefruit, grapefruit juice, Seville oranges, Seville orange
marmalade, or other products containing grapefruit or Seville oranges between the
parent study and entry into the CA study.
14. Any known hypersensitivity or contraindication to AZD1775 or to the components
thereof.
15. Any of the following cardiac diseases currently or within the last 6 months as
defined by the New York Heart Association *Class 2:
* Unstable angina pectoris.
* Congestive heart failure.
* Acute myocardial infarction.
* Conduction abnormality not controlled with pacemaker or medication.
* Significant ventricular or supraventricular arrhythmias (patients with chronic rate-controlled atrial fibrillation in the absence of other cardiac abnormalities are eligible).
16. AZD1775 should not be given to patients who have a history of Torsades de pointes
unless all risk factors that contributed to Torsades have been corrected. AZD1775
has not been studied in patients with ventricular arrhythmias or recent myocardial
infarction.
17. Patient with mean resting QTc interval (specifically QTc calculated using the
Fridericia formula [QTcF]) >450 ms for males and >470 ms for females from
3 electrocardiograms (ECGs) performed within 2 to 5 minutes apart during
screening, or congenital long QT syndrome.
18. Pregnant or lactating female patients.
19. Serious, symptomatic active infection at the time of study entry, or another serious
underlying medical condition that would impair the ability of the patient to receive
study treatment.
20. Active infection with hepatitis B, hepatitis C, or human immunodeficiency virus
(HIV).