Primary Objective: To determine whether the wGRS is associated with recurrent DD. Secondary Objective(s): - To determine whether wGRS is associated with the severity of recurrence- To determine whether risk factors for DD are also associated with…
ID
Source
Brief title
Condition
- Connective tissue disorders (excl congenital)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The presence of recurrent Dupuytren disease.
Secondary outcome
Severity of recurrence.
Background summary
The weighted genetic risk score (wGRS) has shown to be associated with clinical
characteristics of DD (i.e. Dupuytren diathesis ). It is known that the
presence of diathesis features can lead to a more aggressive disease process,
with high recurrence. Because of the association between wGRS and diathesis
features, it can be expected that a high genetic risk score can also lead to an
increased chance of recurrence.
Knowledge about this association can help clinicians to choose the most
effective treatment. Patients with a high genetic risk score might benefit more
from a more aggressive treatment strategy, reducing the chance of recurrence.
Study objective
Primary Objective:
To determine whether the wGRS is associated with recurrent DD.
Secondary Objective(s):
- To determine whether wGRS is associated with the severity of recurrence
- To determine whether risk factors for DD are also associated with recurrent
DD
Study design
Cross-sectional study
Study burden and risks
The burden of participating in this study will be low, because participation
requires a time investment of 20 minutes (and time to travel).
All measurements are observational and non-invasive, so participation has no
risks.
Hanzeplein 1
Groningen 9713 GZ
NL
Hanzeplein 1
Groningen 9713 GZ
NL
Listed location countries
Age
Inclusion criteria
- Dupuytren disease patient
- participant in the GODDAF study (METc2007.067)
- genetic data passed the quality control
- surgical treatment of DD
- written informed consent
Exclusion criteria
- Decisionally incapacitated
- Patients treated for DD with collagenase or radiotherapy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| ClinicalTrials.gov | NCT02983162 |
| CCMO | NL59032.042.16 |